Dominique Emilie

TL;DR: It is shown that a fraction of blood monocyte-derived myeloid dendritic cells (MDCs) express B7-H1, a member of the B7 family, on the cell surface, which could be further upregulated by tumor environmental factors.

TL;DR: Increased serum levels of IL-1 beta and IL-6 in severe PPH are demonstrated, and a role for proinflammatory cytokines in PPH is suggested, and it is suggested that COPD-PH patients with pulmonary hypertension secondary to chronic obstructive pulmonary disease should be considered for lung transplantation.

TL;DR: It is shown that malignant human ovarian epithelial tumor cells express very high levels of stromal-derived factor-1, which induces DC2 precursor (preDC2) chemotaxis and adhesion/transmigration, upregulates preDC2 very late antigen (VLA)-5, and protects preDC1s from tumor macrophage interleukin-10–induced apoptosis, all through CXC chemokine receptor-4.

TL;DR: The risk of TB is higher for patients receiving anti-TNF mAb therapy than for those receiving soluble TNF receptor therapy, and the increased risk with early anti-tumor necrosis factor treatment and the absence of correct chemoprophylactic treatment favor the reactivation of latent TB.

TL;DR: The results indicate that the Ig production by SLE B lymphocytes is largely IL-10 dependent, and that the increased production ofIL-10 by Sle B lymphocyte and monocytes may represent a critical mechanism in the emergence of the autoimmune manifestations of the disease.