H
Helga Kristjansdottir
Researcher at Uppsala University
Publications - 25
Citations - 2166
Helga Kristjansdottir is an academic researcher from Uppsala University. The author has contributed to research in topics: Lupus erythematosus & Population. The author has an hindex of 16, co-authored 24 publications receiving 2048 citations.
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Journal ArticleDOI
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans
Ludmila Prokunina,Casimiro Castillejo-López,Fredrik Öberg,Iva Gunnarsson,Louise Berg,Veronica Magnusson,Anthony J. Brookes,Dmitry Tentler,Helga Kristjansdottir,Gerdur Grondal,Anne Isine Bolstad,Anne Isine Bolstad,Elisabet Svenungsson,Ingrid E. Lundberg,Gunnar Sturfelt,Andreas Jönssen,Lennart Truedsson,Guadalupe Lima,Jorge Alcocer-Varela,Roland Jonsson,Ulf Gyllensten,John B. Harley,Donato Alarcón-Segovia,Kristjan Steinsson,Marta E. Alarcón-Riquelme +24 more
TL;DR: It is shown that one intronic SNP in PDCD1 is associated with development of SLE in Europeans, and this SNP alters a binding site for the runt-related transcription factor 1 (RUNX1) located in an intronic enhancer, suggesting a mechanism through which it can contribute to the development ofSLE in humans.
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Polymorphisms in the Tyrosine Kinase 2 and Interferon Regulatory Factor 5 Genes Are Associated with Systemic Lupus Erythematosus
Snaevar Sigurdsson,Gunnel Nordmark,Harald H H Göring,Katarina Lindroos,Ann-Christin Wiman,Gunnar Sturfelt,Andreas Jönsen,Solbritt Rantapää-Dahlqvist,Bozena Möller,Juha Kere,Sari Koskenmies,Elisabeth Widen,Maija-Leena Eloranta,Heikki Julkunen,Helga Kristjansdottir,Kristjan Steinsson,Gunnar V. Alm,Lars Rönnblom,Ann-Christine Syvänen +18 more
TL;DR: The results support a disease mechanism in SLE that involves key components of the type I IFN system, and identify SNPs that displayed strong signals in joint analysis of linkage and association with SLE.
Journal ArticleDOI
A susceptibility locus for human systemic lupus erythematosus (hSLE1) on chromosome 2q.
Anna-Karin Lindqvist,Kristjan Steinsson,Bo Johanneson,Helga Kristjansdottir,Alfred Àrnasson,Gerdur Grondal,Inger Jonasson,Veronica Magnusson,Gunnar Sturfelt,Lennart Truedsson,Elisabet Svenungsson,Ingrid E. Lundberg,Joseph D. Terwilliger,Ulf Gyllensten,Marta E. Alarcón-Riquelme +14 more
TL;DR: To identify chromosomal regions containing susceptibility loci for systemic lupus erythematosus (SLE), genome scans in families with multiple SLE patients from Iceland, a geographical and genetic isolate, and from Sweden were performed.
Journal ArticleDOI
Increased number of interleukin‐10–producing cells in systemic lupus erythematosus patients and their first‐degree relatives and spouses in Icelandic multicase families
Gerdur Grondal,Helga Kristjansdottir,Brynja Gunnlaugsdottir,Alfred Arnason,Ingrid E. Lundberg,Lars Klareskog,Kristjan Steinsson +6 more
TL;DR: Data support the hypothesis that IL-10 production may be genetically determined, and may predispose one toward development of SLE, and suggest that not only genetic but also environmental factors may be of importance in determining IL- 10 production.
Journal ArticleDOI
Fine mapping of the SLEB2 locus involved in susceptibility to systemic lupus erythematosus
Veronica Magnusson,Anna-Karin Lindqvist,Casimiro Castillejo-López,Helga Kristjansdottir,Kristjan Steinsson,Gerdur Grondal,Gunnar Sturfelt,Lennart Truedsson,Elisabet Svenungsson,Ingrid E. Lundberg,I. Gunnarsson,Anne Isine Bolstad,H J Haga,Roland Jonsson,Lars Klareskog,Jorge Alcocer-Varela,Donato Alarcón-Segovia,Joseph D. Terwilliger,Ulf Gyllensten,Marta E. Alarcón-Riquelme +19 more
TL;DR: The results support the presence of the SLEB2 locus at 2q37 and show evidence for association in the single-case and multicase families with locus GAAT3C11 (P < 0.0003), and weak evidence was obtained for several markers located telomeric to D2S125 in the multicase Families.