D
Dong Hyun Kim
Researcher at University of California, San Diego
Publications - 14
Citations - 945
Dong Hyun Kim is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Spindle checkpoint & Chromosome. The author has an hindex of 9, co-authored 14 publications receiving 575 citations. Previous affiliations of Dong Hyun Kim include University of Texas Health Science Center at San Antonio & Ludwig Institute for Cancer Research.
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Journal ArticleDOI
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
Peter Ly,Levi S. Teitz,Dong Hyun Kim,Ofer Shoshani,Helen Skaletsky,Daniele Fachinetti,David C. Page,Don W. Cleveland +7 more
TL;DR: An inducible Y centromere-selective inactivation strategy is developed by exploiting a CENP-A/histone H3 chimaera to directly examine the fate of missegregated chromosomes in otherwise diploid human cells, and initial errors in cell division can provoke further genomic instability through fragmentation of micronuclear DNAs coupled to NHEJ-mediated reassembly in the subsequent interphase.
Journal ArticleDOI
Chromothripsis drives the evolution of gene amplification in cancer.
Ofer Shoshani,Simon F. Brunner,Rona Yaeger,Peter Ly,Yael Nechemia-Arbely,Dong Hyun Kim,Rongxin Fang,Guillaume A. Castillon,Miao Yu,Julia S. Z. Li,Ying Sun,Mark H. Ellisman,Bing Ren,Peter J. Campbell,Peter J. Campbell,Don W. Cleveland +15 more
TL;DR: In this paper, the authors used whole-genome sequencing of clonal cell isolates that developed chemotherapeutic resistance to show that chromothripsis is a major driver of circular extrachromosomal DNA (ecDNA) amplification through mechanisms that depend on poly(ADP-ribose) polymerases (PARP) and the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs).
Journal ArticleDOI
Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.
Peter Ly,Simon F. Brunner,Ofer Shoshani,Dong Hyun Kim,Weijie Lan,Tatyana Pyntikova,Adrienne M. Flanagan,Adrienne M. Flanagan,Sam Behjati,Sam Behjati,David C. Page,Peter J. Campbell,Don W. Cleveland +12 more
TL;DR: It is concluded that individual chromosome segregation errors during mitotic cell division are sufficient to drive extensive structural variations that recapitulate genomic features commonly associated with human disease.
Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining
Peter Ly,Dong Hyun Kim,Ofer Shoshani,Helen Skaletsky,Daniele Fachinetti,Don W. Cleveland,Levi S. Teitz,David C. Page +7 more
Journal ArticleDOI
The AAA+ ATPase TRIP13 remodels HORMA domains through N‐terminal engagement and unfolding
Qiaozhen Ye,Dong Hyun Kim,Ihsan Dereli,Scott C. Rosenberg,Scott C. Rosenberg,Goetz Hagemann,Franz Herzog,Attila Tóth,Don W. Cleveland,Don W. Cleveland,Kevin D. Corbett +10 more
TL;DR: X‐ray crystallography and crosslinking mass spectrometry is combined to outline how TRIP13 recognizes MAD2 with the help of the adapter protein p31comet, highlighting a conserved mechanism for recognition and disassembly of HORMA domain–closure motif complexes by TRIP 13.