H
Helen Skaletsky
Researcher at Massachusetts Institute of Technology
Publications - 73
Citations - 27580
Helen Skaletsky is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Y chromosome & Gene. The author has an hindex of 38, co-authored 67 publications receiving 26345 citations. Previous affiliations of Helen Skaletsky include Howard Hughes Medical Institute.
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Book ChapterDOI
Primer3 on the WWW for general users and for biologist programmers.
Steve Rozen,Helen Skaletsky +1 more
TL;DR: This chapter assumes acquaintance with the principles and practice of PCR, as outlined in, for example, refs.
Journal ArticleDOI
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Helen Skaletsky,Tomoko Kuroda-Kawaguchi,Patrick Minx,Holland S. Cordum,LaDeana W. Hillier,Laura G. Brown,Sjoerd Repping,Tatyana Pyntikova,Johar Ali,Tamberlyn Bieri,Asif T. Chinwalla,Andrew Delehaunty,Kim D. Delehaunty,Hui Du,Ginger A. Fewell,Lucinda Fulton,Robert S. Fulton,Tina Graves,Shunfang Hou,Philip Latrielle,Shawn Leonard,Elaine R. Mardis,Rachel Maupin,John Douglas Mcpherson,Tracie L. Miner,William E. Nash,Christine Nguyen,Philip Ozersky,Kymberlie H. Pepin,Susan M. Rock,Tracy Rohlfing,Kelsi Scott,Brian Schultz,Cindy Strong,Aye Mon Tin-Wollam,Shiaw-Pyng Yang,Robert H. Waterston,Richard K. Wilson,Steve Rozen,David C. Page +39 more
TL;DR: The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length, and is a mosaic of heterochromatic sequences and three classes of euchromatics sequences: X-transposed, X-degenerate and ampliconic.
Journal ArticleDOI
The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men.
Tomoko Kuroda-Kawaguchi,Helen Skaletsky,Helen Skaletsky,Laura G. Brown,Laura G. Brown,Patrick Minx,Holland S. Cordum,Robert H. Waterston,Richard K. Wilson,Sherman J. Silber,Robert D. Oates,Steve Rozen,Steve Rozen,David C. Page,David C. Page +14 more
TL;DR: The complete nucleotide sequence of AZFc was determined by identifying and distinguishing between near-identical amplicons (massive repeat units) using an iterative mapping–sequencing process.
Journal ArticleDOI
Abundant gene conversion between arms of palindromes in human and ape Y chromosomes
Steve Rozen,Helen Skaletsky,Janet D. Marszalek,Patrick Minx,Holland S. Cordum,Robert H. Waterston,Richard K. Wilson,David C. Page +7 more
TL;DR: It is concluded that during recent evolution, an average of approximately 600 nucleotides per newborn male have undergone Y–Y gene conversion, which has had an important role in the evolution of multi-copy testis gene families in the MSY.
Journal ArticleDOI
Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
Daniel W. Bellott,Jennifer F. Hughes,Helen Skaletsky,Laura G. Brown,Tatyana Pyntikova,Ting-Jan Cho,Natalia Koutseva,Sara Zaghlul,Tina Graves,Susie Rock,Colin Kremitzki,Robert S. Fulton,Shannon Dugan,Yan Ding,Donna Morton,Ziad Khan,Lora Lewis,Christian J. Buhay,Qiaoyan Wang,Jennifer Watt,Michael Holder,Sandy Lee,Lynne V. Nazareth,Jessica Alföldi,Steve Rozen,Donna M. Muzny,Wesley C. Warren,Richard A. Gibbs,Richard K. Wilson,David C. Page +29 more
TL;DR: It is proposed that beyond its roles in testis determination and spermatogenesis, the Y chromosome is essential for male viability, and has unappreciated roles in Turner’s syndrome and in phenotypic differences between the sexes in health and disease.