Dongdong Su

TL;DR: The preparation of a lipophilic cationic dye 1 (Mito-Ratio-SO2), which targets the mitochondria in living cells and is sensitive to the presence of SO2 derivatives, is reported, which is highly selective for sulfite over other bio-species including H2S.

TL;DR: This work proposes an approach for developing a new stable NIR dye platform with an optically tunable group to eliminate false signals using the combination of dyes screening and rational design strategy, and expects the high-fidelity NIR dyed group could provide a convenient and efficient tool for the development of future probes applied in the pathological environment.

TL;DR: This tutorial review will summarize the concept and mechanisms of MICE for developing single-molecular fluorescent probes, present unique advantages of Mice based sensors, demonstrate their various applications, and discuss technical challenges in this field.

TL;DR: Taking advantages of the high tissue-penetration capability of near-infrared excitation/emission, these nanoprobes achieve real-time monitoring of hepatot toxicity in living animals, thereby providing a convenient screening strategy for assessing hepatotoxicity of synthetic drugs.

TL;DR: A multisite-binding switchable fluorescent probe, ATP-Red 1, which selectively and rapidly responds to intracellular concentrations of ATP, is reported, which successfully observed not only the decreased mitochondrial ATP levels in the presence of KCN and starvation state, but also the increased mitochondrial ATP Levels in the early stage of cell apoptosis.