Xiao Zeng

TL;DR: It is demonstrated that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons and evoked dopamine release from genetically tagged neurons in the ventral tegmental area and triggered memory recall.

TL;DR: Taking advantages of the high tissue-penetration capability of near-infrared excitation/emission, these nanoprobes achieve real-time monitoring of hepatot toxicity in living animals, thereby providing a convenient screening strategy for assessing hepatotoxicity of synthetic drugs.

TL;DR: An experimental design, based on a combination of core-shell-structured upconversion nanoparticles and diarylethene photochromic molecules, for achieving rewritable optical memory is reported, offering a convenient and versatile optical method for controlling the process of data writing and erasing with high spatiotemporal resolution.

TL;DR: An overview of advances in developing new modalities for neural circuitry modulation utilizing upconversion‐nanoparticle‐mediated optogenetics is presented, which have led to minimally invasive optical stimulation and inhibition of neurons with substantially improved selectivity, sensitivity, and spatial resolution.

TL;DR: It is found that ligand-free lanthanide-doped nanoparticles induce intracellular ATP deprivation of HeLa cells, resulting in a significant decrease in cell viability after exposure for 7 days, and attribute the particle-induced cell death to two distinct cell death pathways, autophagy and apoptosis.