Dongfang Yang

TL;DR: Con concurrent use of both drugs would inhibit the activation of oseltamivir, thus making this antiviral agent therapeutically inactive, which is epidemiologically of significance because people who receive osel Tamsivir and clopidogrel simultaneously may maintain susceptibility to influenza infection or a source of spreading influenza virus if already infected.

TL;DR: The isoform-specific hydrolysis of aspirin and clopidogrel suggests that these two antithrombogenic agents may have pharmacokinetic interactions with different sets of ester drugs, and the altered Hydrolysis by polymorphic mutants provides a molecular explanation to the interindividual variation.

TL;DR: A large inter-individual variability was detected in mRNA, protein, protein and hydrolytic activity within the same age group, particularly in the fetal and child groups, and this has important pharmacological and toxicological implications.

TL;DR: Findings establish that the survivin gene is a transcription target of DEC1, and induction of survivin is at least in part responsible for DEC1 antiapoptosis.

TL;DR: The results functionally distinguish DEC1 from other bHLH proteins and directly link this factor to oncogenesis.