Christopher B. Black

TL;DR: Con concurrent use of both drugs would inhibit the activation of oseltamivir, thus making this antiviral agent therapeutically inactive, which is epidemiologically of significance because people who receive osel Tamsivir and clopidogrel simultaneously may maintain susceptibility to influenza infection or a source of spreading influenza virus if already infected.

TL;DR: The isoform-specific hydrolysis of aspirin and clopidogrel suggests that these two antithrombogenic agents may have pharmacokinetic interactions with different sets of ester drugs, and the altered Hydrolysis by polymorphic mutants provides a molecular explanation to the interindividual variation.

TL;DR: The results suggest that other thiazolidinediones may have the potential to cause clinically significant drug interactions at sufficiently high doses and there is potential for interactions with CYP2C8 substrates.

TL;DR: Cryopreserved hepatocytes and cytosolic fractions from animals and humans provide qualitatively similar data within the species, indicating that results from animal studies cannot be safely extrapolated to humans.

TL;DR: The data indicates that CI-1034 is an inhibitor of major hepatic transporters and inhibition of bile efflux may have contributed to the observed clinical hepatotoxicity, and recommends that in vitro drug-drug interaction panels include inhibition and induction studies with transporter and drug metabolizing enzymes.