S
Sangkyu Lee
Researcher at Kyungpook National University
Publications - 212
Citations - 5911
Sangkyu Lee is an academic researcher from Kyungpook National University. The author has contributed to research in topics: Metabolite & Chemistry. The author has an hindex of 25, co-authored 188 publications receiving 4357 citations. Previous affiliations of Sangkyu Lee include University of Chicago & Korea Institute of Science and Technology.
Papers
More filters
Journal ArticleDOI
Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification
Minjia Tan,Hao Luo,Sangkyu Lee,Fulai Jin,Jeong Soo Yang,Emilie Montellier,Thierry Buchou,Zhongyi Cheng,Sophie Rousseaux,Nisha Rajagopal,Zhike Lu,Zhen Ye,Qin Zhu,Joanna Wysocka,Yang Ye,Saadi Khochbin,Bing Ren,Yingming Zhao +17 more
TL;DR: The identification of 67 previously undescribed histone modifications is reported, increasing the current number of known histone marks by about 70%, and lysine crotonylation (Kcr) is investigated, confirming that it represents an evolutionarily-conserved histone posttranslational modification.
Journal ArticleDOI
Metabolic regulation of gene expression by histone lactylation
Di Zhang,Zhanyun Tang,He Huang,He Huang,Guolin Zhou,Chang Cui,Yejing Weng,Wenchao Liu,Sunjoo Kim,Sangkyu Lee,Mathew Perez-Neut,Jun Ding,Daniel M. Czyż,Rong Hu,Zhen Ye,Maomao He,Y. George Zheng,Howard A. Shuman,Lunzhi Dai,Lunzhi Dai,Bing Ren,Robert G. Roeder,Lev Becker,Yingming Zhao +23 more
TL;DR: The results suggest that an endogenous ‘lactate clock’ in bacterially challenged M1 macrophages turns on gene expression to promote homeostasis, and represents an opportunity to improve the understanding of the functions of lactate and its role in diverse pathophysiological conditions, including infection and cancer.
Journal ArticleDOI
Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ
Li Qiang,Liheng Wang,Ning Kon,Wenhui Zhao,Sangkyu Lee,Yiying Zhang,Michael Rosenbaum,Yingming Zhao,Wei Gu,Stephen R. Farmer,Domenico Accili +10 more
TL;DR: It is proposed that SirT1-dependent P parγ deacetylation is a form of selective Pparγ modulation of potential therapeutic import in order to staunch the current obesity epidemic.
Journal ArticleDOI
Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Zhongyu Xie,Di Zhang,Dongjun Chung,Dongjun Chung,Zhanyun Tang,He Huang,Lunzhi Dai,Shankang Qi,Jing-Ya Li,Gozde Colak,Yue Chen,Chunmei Xia,Chao Peng,Hai Bin Ruan,Matt Kirkey,Dan-Li Wang,Lindy Jensen,Oh Kwang Kwon,Sangkyu Lee,Scott D. Pletcher,Minjia Tan,David B. Lombard,Kevin P. White,Hongyu Zhao,Jia Li,Robert G. Roeder,Xiaoyong Yang,Yingming Zhao +27 more
TL;DR: Histone Kbhb represents a new epigenetic regulatory mark that couples metabolism to gene expression, offering a new avenue to study chromatin regulation and diverse functions of β-hydroxybutyrate in the context of important human pathophysiological states, including diabetes, epilepsy, and neoplasia.
Journal ArticleDOI
Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease
TL;DR: The study suggests that PKA, a cAMP-dependent kinase involved in regulating dopamine physiology, is a potential upstream kinase that phosphorylates LRRK2 at S935 and proposes that 14-3-3 is an important regulator of L RRK2-mediated cellular functions.