M
Mark S. Jensen
Researcher at Merck & Co.
Publications - 33
Citations - 659
Mark S. Jensen is an academic researcher from Merck & Co.. The author has contributed to research in topics: Trifluoromethyl & Aryl. The author has an hindex of 11, co-authored 33 publications receiving 636 citations.
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Journal ArticleDOI
An improved protocol for the preparation of 3-pyridyl- and some arylboronic acids.
Wenjie Li,Dorian P. Nelson,Mark S. Jensen,R. Scott Hoerrner,Dongwei Cai,Robert D. Larsen,Paul J. Reider +6 more
TL;DR: 3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium-halogen exchange and "in situ quench", and this technique was further studied and evaluated on other aryl halides in the preparation of aRYlboronic acids.
Journal ArticleDOI
Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine
Wenjie Li,Dorian P. Nelson,Mark S. Jensen,R. Scott Hoerrner,Gary Javadi,Dongwei Cai,Robert D. Larsen +6 more
TL;DR: This work has reported an efficient one-step synthesis of 3-arylimidazo[1,2-a]pyrimidines from the unsubstituted heterocycle with a catalytic amount of palladium.
Journal ArticleDOI
Synthesis of an anti-methicillin-resistant Staphylococcus aureus (MRSA) carbapenem via stannatrane-mediated Stille coupling.
Mark S. Jensen,Chunhua Yang,Yi Hsiao,Nelo R. Rivera,Kenneth M. Wells,John Y. L. Chung,Nobuyoshi Yasuda,David L. Hughes,Paul J. Reider +8 more
TL;DR: A short synthesis of carbapenem 1 is described, which involves the cross-coupling of an enol triflate with an amino-substituted sp3 carbon and utilizes a stannatrane as the heteroalkyl transfer reagent.
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An Efficient Synthesis of an αvβ3 Antagonist
Nobuyoshi Yasuda,Yi Hsiao,Mark S. Jensen,Nelo R. Rivera,Chunhua Yang,Kenneth M. Wells,James Yau,Michael Palucki,Lushi Tan,Peter G. Dormer,Ralph P. Volante,David L. Hughes,Paul J. Reider +12 more
TL;DR: A practical preparation of an alpha(v)beta(3) antagonist is reported, which consists of three key components, a tetrahydronaphthyridine moiety, a beta-alanine moieties, and a central imidazolidone moiety.
Journal ArticleDOI
Efficient Synthesis of a GABAA α2,3-Selective Allosteric Modulator via a Sequential Pd-Catalyzed Cross-Coupling Approach
Mark S. Jensen,R. Scott Hoerrner,Wenjie Li,Dorian P. Nelson,Gary Javadi,Peter G. Dormer,Dongwei Cai,Robert D. Larsen +7 more
TL;DR: A practical synthesis of 2-[3-(4-fluoro-3-pyridin- 3-yl-phenyl)-imidazo[1,2-a]pyridine boronic acid 4]-propan-2-ol (1), an oral GABA(A) alpha(2/3)-selective agonist, is described.