Donna E. Prunkard

TL;DR: The functional cloning of a murine complementary DNA encoding a ligand for the receptor encoded by the c-mpl proto-oncogene is reported, and results strongly suggest that theligand for c-Mpl is thrombopoietin.

TL;DR: In ob/ob mice, systemic administration of leptin inhibits NPY gene overexpression through a specific action in the arcuate nucleus and exerts a hypoglycemic action that is partly independent of its weight-reducing effects.

TL;DR: A structural, profile-based algorithm was used to identify interleukin 20 (IL-20), a novel IL-10 homolog, and an IL-20 receptor was identified as a heterodimer of two orphan class II cytokine receptor subunits that are expressed in skin and are dramatically upregulated in psoriatic skin.

TL;DR: In this article, materials and methods for producing fibrinogen in transgenic non-human mammals are disclosed. DNA segments encoding Aα, Bβ, and η chains of fibrINogen are introduced into the germ line of a nonhuman mammal, and the mammal or its female progeny produces milk containing FIB expressed from the introduced DNA segments.

TL;DR: These studies represent the first report of high-level biosynthesis and secretion of a functional, complex, hexameric protein in the milk of a transgenic animal.