Donne Majoor

TL;DR: It is shown that sustained BRAFV600E expression in human melanocytes induces cell cycle arrest, which is accompanied by the induction of both p16INK4a and senescence-associated acidic β-galactosidase (SA-β-Gal) activity, a commonly usedsenescence marker.

TL;DR: Investigation of whether biological factors related to radiosensitivity and chemosensitivity have prognostic significance in non‐small‐cell‐lung‐cancer patients treated with daily low doses of cisplatin and radiotherapy found that cisPlatin‐DNA‐adductStaining remained an independent prognostic factor, with shorter survival times for patients with low adduct staining.

TL;DR: The differential distribution of co‐stimulatory molecules in different compartments of normal human lymphoid tissue in situ indicates that these interactions play a distinctive role in different stages of B cell differentiation and in the immune response.

TL;DR: This study is the first in vivo report of the radiation-induced p53 apoptotic response in patients and suggests that this apoptosis response is not immunologically silent, which are important arguments to advocate the use of low-dose radiotherapy as an effective palliative treatment for follicular lymphoma.

TL;DR: The results indicate that in humans IGF-system components are differentially expressed in the colorectum, and suggest that local and circulating components of the IGF- system areDifferentially regulated.