F
Florry A. Vyth-Dreese
Researcher at Netherlands Cancer Institute
Publications - 57
Citations - 3674
Florry A. Vyth-Dreese is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 28, co-authored 57 publications receiving 3509 citations. Previous affiliations of Florry A. Vyth-Dreese include Leiden University Medical Center.
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Journal ArticleDOI
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells
Willem W. Overwijk,Marc R. Theoret,Steven E. Finkelstein,Deborah R. Surman,Laurina A. de Jong,Florry A. Vyth-Dreese,Trees A. M. Dellemijn,Paul A. Antony,Paul J. Spiess,Douglas C. Palmer,David M. Heimann,Christopher A. Klebanoff,Zhiya Yu,Leroy N. Hwang,Lionel Feigenbaum,Ada M. Kruisbeek,Steven A. Rosenberg,Nicholas P. Restifo +17 more
TL;DR: It is found that tumor growth and lethality were unchanged in mice even after adoptive transfer of large numbers of T cells specific for an MHC class I–restricted epitope of the self/tumor antigen gp100, illustrating that adoptive transferof T cells and IL-2 can augment the function of a cancer vaccine.
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Autoimmune destruction of skin melanocytes by perilesional T cells from vitiligo patients.
Jasper G. van den Boorn,Debby Konijnenberg,Trees A. M. Dellemijn,J.P. Wietze van der Veen,Jan D. Bos,Cornelis J. M. Melief,Florry A. Vyth-Dreese,Rosalie M. Luiten +7 more
TL;DR: Perilesional cytotoxic T cells eradicate pigment cells, the characteristic hallmark of vitiligo, thereby providing evidence of T cells being able to mediate targeted autoimmune tissue destruction.
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In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens
Anne M. Dickinson,Xiao-Nong Wang,Lisbet Sviland,Florry A. Vyth-Dreese,Graham Jackson,Ton N. Schumacher,John B. A. G. Haanen,Tuna Mutis,Els Goulmy +8 more
TL;DR: Results provide the first in situ dissection of GvH effects by mHag-specific CTLs and show that ubiquitously expressed mHags are the prime targets of GVH disease.
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STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression.
Ferenc A. Scheeren,Marianne Naspetti,Sean A. Diehl,Remko Schotte,Remko Schotte,Maho Nagasawa,Maho Nagasawa,Erwin Wijnands,Ramon Gimeno,Florry A. Vyth-Dreese,Bianca Blom,Bianca Blom,Hergen Spits,Hergen Spits +13 more
TL;DR: Using RNA interference and ectopic expression of constitutively activated forms of STAT5, it is demonstrated here a function for STAT5 in the self-renewal of B cells in vitro and data indicate that activation ofSTAT5 is involved in regulation of memory B cell differentiation.
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Expression of pT∝ mRNA in a Committed Dendritic Cell Precursor in the Human Thymus
TL;DR: The thymicpre-DC are very similar to the recently characterized pre-DC found in the T cell areas of the tonsil, and it is suggested that these pre- DC populations are of lymphoid origin.