D
Dora Angelicheva
Researcher at University of Western Australia
Publications - 52
Citations - 3088
Dora Angelicheva is an academic researcher from University of Western Australia. The author has contributed to research in topics: Population & Founder effect. The author has an hindex of 29, co-authored 52 publications receiving 2944 citations. Previous affiliations of Dora Angelicheva include Sofia Medical University & Harry Perkins Institute of Medical Research.
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Journal ArticleDOI
N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom.
Luba Kalaydjieva,Luba Kalaydjieva,David Gresham,Rebecca Gooding,Lisa Heather,Frank Baas,Rosalein R. de Jonge,Karin Blechschmidt,Dora Angelicheva,David Chandler,Penelope Worsley,André Rosenthal,Rosalind H.M. King,P.K. Thomas +13 more
TL;DR: Sequence analysis of two genes located in the critical region identified the founder HMSNL mutation: a premature-termination codon at position 148 of the N-myc downstream-regulated gene 1 (NDRG1).
Journal ArticleDOI
The origin of the major cystic fibrosis mutation (ΔF508) in European populations
Núria Morral,Jaume Bertranpetit,Xavier Estivill,V. Nunes,Teresa Casals,Javier Giménez,André Reis,R. Varon-Mateeva,Milan Macek,Milan Macek,Luba Kalaydjieva,Dora Angelicheva,R. Dancheva,Giovanni Romeo,Maria Pia Russo,S. Garnerone,Gabriella Restagno,Maurizio Ferrari,C. Magnani,Mireille Claustres,Marie Desgeorges,Marianne Schwartz,Martin Schwarz,Bruno Dallapiccola,Giuseppe Novelli,Claude Férec,M. De Arce,M. Nemeti,M. Nemeti,Juha Kere,Maria Anvret,Niklas Dahl,Ludovit Kadasi +32 more
TL;DR: Haplotype data demonstrate that ΔF508 occurred more than 52,000 years ago, in a population genetically distinct from any present European group, and spread throughout Europe in chronologically distinct expansions, which are responsible for the different frequencies of ΔF50 in Europe.
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Origins and Divergence of the Roma (Gypsies)
David Gresham,Bharti Morar,Peter A. Underhill,Giuseppe Passarino,Alice A. Lin,Cheryl Wise,Dora Angelicheva,Francesc Calafell,Peter J. Oefner,Peidong Shen,Ivailo Tournev,Rosario de Pablo,Vaidutis Kuĉinskas,Anna Pérez-Lezaun,Elena Marushiakova,Vesselin Popov,Luba Kalaydjieva,Luba Kalaydjieva +17 more
TL;DR: Principal-components analysis and analysis of molecular variance indicate that genetic structure in extant endogamous Romani populations has been shaped by genetic drift and differential admixture and correlates with the migrational history of the Roma in Europe.
Journal ArticleDOI
Gene mapping in Gypsies identifies a novel demyelinating neuropathy on chromosome 8q24.
Luba Kalaydjieva,Luba Kalaydjieva,Joachim Hallmayer,David Chandler,Alexey Savov,Amelia Nikolova,Dora Angelicheva,Rosalind H. H. King,Boryana Ishpekova,K. Honeyman,Francesc Calafell,Alexander Shmarov,Julia Petrova,Ivailo Turnev,Anna Hristova,Momchil Moskov,Stella Stancheva,Iva Petkova,Alan H. Bittles,Veneta Georgieva,Lefkos T. Middleton,P. K. Thomas +21 more
TL;DR: This study is the first example of mapping a disease gene in endogamous Gypsy groups by locating a novel demyelinating neuropathy to a narrow interval on chromosome 8q24 and showing that the disease is caused by a single mutation whose origin predates the divergence of these groups.
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From Asia to Europe: mitochondrial DNA sequence variability in Bulgarians and Turks
TL;DR: Mean pairwise differences suggest that a demographic expansion occurred sequentially in the Middle East, through Turkey, to the rest of Europe (Bulgaria included), and would correspond to the arrival of anatomically modern humans in Europe.