D
Dorothea Fiedler
Researcher at Humboldt University of Berlin
Publications - 98
Citations - 5794
Dorothea Fiedler is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Inositol & Kinase. The author has an hindex of 33, co-authored 85 publications receiving 5000 citations. Previous affiliations of Dorothea Fiedler include University of California, San Francisco & Howard Hughes Medical Institute.
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An unconventional gatekeeper mutation sensitizes inositol hexakisphosphate kinases to an allosteric inhibitor
Sarah Hostachy,Gillian L. Dornan,Martin Neuenschwander,Carola Seyffarth,Volker Haucke,Anja Schütz,Jens Peter von Kries,Dorothea Fiedler +7 more
TL;DR: Inositol hexakisphosphate kinases (IP6Ks) are emerging as relevant pharmacological targets because a multitude of disease-related phenotypes has been associated with their function as discussed by the authors .
Journal ArticleDOI
Synthetic Pyrophosphorylation Methods and Their Use in Chemical Biology
TL;DR: In this article, a robust method to incorporate pyrophosphate residues into peptide sequences was developed to explore the signaling role of protein pyrophophosphorylation, a recently discovered modification mediated by the inositol pyrophosate messengers.
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Chemoselective Labeling and Immobilization of Phosphopeptides with Phosphorimidazolide Reagents
TL;DR: It is shown that a biotinylated, photo-cleavable phosphorimidazolide reagent permits the immobilization and subsequent cleavage of phosphopeptides, and this mild and selective strategy expands the current repertoire forosphopeptide chemical modification with the potential to enrich and identify new phosphorylation sites in the future.
Journal ArticleDOI
Nucleolar Architecture Is Modulated by a Small Molecule, the Inositol Pyrophosphate 5-InsP7
Soumya Prakash Sahu,Jacob Gordon,Chunfang Gu,Mack Sobhany,Dorothea Fiedler,Robin E. Stanley,Stephen B. Shears +6 more
TL;DR: Inositol pyrophosphates (PP-InsPs) are a functionally diverse family of eukaryotic molecules that deploy a highly-specialized array of phosphate groups as a combinatorial cell-signaling code as discussed by the authors .
Journal ArticleDOI
Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe
Natascha Andrea Kuenzel,Abel R. Alcázar-Román,Adolfo Saiardi,Simon M. Bartsch,S Daunaraviciute,Dorothea Fiedler,Ursula Fleig +6 more
TL;DR: The perturbations of the inositol polyphosphate and IPP pathways demonstrate that kinetochore architecture depends solely on IP8 and not on other IPPs, and conclude that chromosome transmission fidelity is controlled by IP8 via an interplay between entry into mitosis, kinetchore architecture and spindle dynamics.