Dorothea Fiedler

TL;DR: It is shown that IP kinases are essential for necroptosis triggered by death receptor activation, herpesvirus infection, or a pro-necrotic MLKL mutant, and that a highly phosphorylated product, but not a lowlyosphorylated precursor, potently displaces theMLKL auto-inhibitory brace region.

TL;DR: Guest displacement reactions demonstrate the sensitivity of guest exchange to thermodynamic endohedral guest binding affinities and blocking the exohedral host sites with high concentrations of the smaller NMe(4)(+) cation (a weak endo Cathedral guest) enhances PEt(4)+) for NEt( 4)(+) guest exchange rates.

TL;DR: This study provides a new algorithm for reconstruction of stable complexes from a variety of heterogeneous biological assays and provides novel insights regarding the protein-protein interaction network, reinterpreting the finding that “hubs” in the network are enriched for being essential, showing instead that essential proteins tend to be clustered together in essential complexes and that these essential complexes tend to been large.

TL;DR: It is demonstrated that IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the TTT complex, thereby stabilizing DNA-PKcs and ATM and stimulating p53 phosphorylated at serine 15 to activate the cell death program in human cancer cells and in murine B cells.

TL;DR: It is reported that deletion of two diphosphoinositol pentakisphosphate kinases VIH1/2 impairs plant growth and leads to constitutive Pi starvation responses, allowing plants to maintain sufficient Pi levels.