D
Dorothea Fiedler
Researcher at Humboldt University of Berlin
Publications - 98
Citations - 5794
Dorothea Fiedler is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Inositol & Kinase. The author has an hindex of 33, co-authored 85 publications receiving 5000 citations. Previous affiliations of Dorothea Fiedler include University of California, San Francisco & Howard Hughes Medical Institute.
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Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry (CE-ESI-MS)
Danye Qiu,Miranda S. C. Wilson,Verena B. Eisenbeis,Robert K. Harmel,Esther Riemer,Thomas M. Haas,Christopher Wittwer,Nikolaus Jork,Chunfang Gu,Stephen B. Shears,Gabriel Schaaf,Bernd Kammerer,Dorothea Fiedler,Adolfo Saiardi,Henning J. Jessen +14 more
TL;DR: In this article, the analysis of myo-inositol pyrophosphates (PP-InsPs) is a daunting challenge due to the large number of possible isomers, the absence of a chromophore, the low abundance, and the instability of the esters and anhydrides.
Supporting Online Material for Rewiring of Genetic Networks in Response to DNA Damage
Sourav Bandyopadhyay,Monika Mehta,Dwight Kuo,Min-Kyung Sung,Ryan Chuang,Eric J. Jaehnig,Bernd Bodenmiller,Katherine Licon,Wilbert Copeland,Michael Shales,Dorothea Fiedler,Janusz Dutkowski,Kevan M. Shokat,Richard D. Kolodner,Ruedi Aebersold,Michael-Christopher Keogh,Nevan J. Krogan,Trey Ideker +17 more
Journal ArticleDOI
Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling
Jiude Qi,Weiwei Cheng,Zhe Gao,Yuanyuan Chen,Megan L. Shipton,David Furkert,Alfred C. Chin,Andrew M. Riley,Dorothea Fiedler,Barry V. L. Potter,Chenglai Fu +10 more
TL;DR: In this article , the antifungal drug itraconazole has been repurposed to anti-angiogenic agent, but the mechanisms of action have been elusive.
Journal ArticleDOI
Chemical Tools for Interrogating Inositol Pyrophosphate Structure and Function
TL;DR: The inositol pyrophosphates (PP-InsPs) are a unique group of intracellular messengers that represent some of the most highly phosphorylated molecules in nature as mentioned in this paper.
Journal ArticleDOI
Real-time monitoring of the sialic acid biosynthesis pathway by NMR
Jacob Lucián Gorenflos López,Peter Schmieder,Kristin Kemnitz-Hassanin,Hatice Ceyda Asikoglu,Arif Çelik,Christian E. Stieger,Dorothea Fiedler,Stephan Hinderlich,Christian P. R. Hackenberger +8 more
TL;DR: In this article , a real-time NMR analysis of sialic acid biosynthesis was performed using recombinant enzymes, in particular using UDP-N-acetylglucosamine 2-epimerase (GNE) or Nacetylmannosamine kinase (MNK), in cytosolic rat liver extract.