D
Dorothea Fiedler
Researcher at Humboldt University of Berlin
Publications - 98
Citations - 5794
Dorothea Fiedler is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Inositol & Kinase. The author has an hindex of 33, co-authored 85 publications receiving 5000 citations. Previous affiliations of Dorothea Fiedler include University of California, San Francisco & Howard Hughes Medical Institute.
Papers
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Journal ArticleDOI
Dose-dependent effects of focal fractionated irradiation on secondary malignant neoplasms in Nf1 mutant mice.
Jean L. Nakamura,Connie Phong,Emile Pinarbasi,Scott C. Kogan,Scott R. VandenBerg,Andrew E. Horvai,Bruce A. Faddegon,Dorothea Fiedler,Kevan M. Shokat,Benjamin T. Houseman,Richard C. Chao,Russell O. Pieper,Kevin Shannon +12 more
TL;DR: A novel technique for administering focal fractionated irradiation will facilitate mechanistic and translational studies of SMNs and reveal discrete patterns of somatic Nf1 and Trp53 inactivation and hyperactive Ras signaling in many radiation-induced solid tumors.
Journal ArticleDOI
Activity of the p110-α subunit of phosphatidylinositol-3-kinase is required for activation of epithelial sodium transport
Jian Wang,Zachary A. Knight,Dorothea Fiedler,Olusegun Williams,Kevan M. Shokat,David A. Pearce +5 more
TL;DR: The data support the conclusion that ENaC-dependent Na(+) current is controlled exclusively by p110-alpha, the same isoform that is the principal mediator of insulin effects on glucose metabolism, and lacks any dependence on p 110-beta.
Journal ArticleDOI
A Fluorescent Sensor and Gel Stain for Detection of Pyrophosphorylated Proteins
TL;DR: The design and synthesis of a fluorescent sensor of diphosphate esters along with its application for in-gel detection and competent stain for visualization of pyrophosphorylated proteins in polyacrylamide gels are described.
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InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics.
Soumyadip Sahu,Zhenzhen Wang,Xinfu Jiao,Chunfang Gu,Nikolaus Jork,Christopher Wittwer,Xingyao Li,Sarah Hostachy,Dorothea Fiedler,Huanchen Wang,Henning J. Jessen,Megerditch Kiledjian,Stephen B. Shears +12 more
TL;DR: regulation of mRNA stability and P-body dynamics by the inositol pyrophosphate signaling molecule 5-InsP7 (5-diphosphoinositol pentakisphosphate) is described.
Journal ArticleDOI
Scalable Chemoenzymatic Synthesis of Inositol Pyrophosphates.
TL;DR: A robust and scalable strategy for the synthesis of various PP-InsPs is reported, relying on the highly active inositol hexakisphosphate kinase A (IP6KA) from Entamoeba histolytica and the kinase domain of human diphosphoinositol pentakisph phosphate kinase 2 (PPIP5K2).