D
Dorothea Fiedler
Researcher at Humboldt University of Berlin
Publications - 98
Citations - 5794
Dorothea Fiedler is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Inositol & Kinase. The author has an hindex of 33, co-authored 85 publications receiving 5000 citations. Previous affiliations of Dorothea Fiedler include University of California, San Francisco & Howard Hughes Medical Institute.
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Journal ArticleDOI
Photoswitchable Inhibitors to Optically Control Specific Kinase Activity.
Ellen Teichmann,Florian Römpp,Ruthey Vivier,Matthew A. Hulverson,Wesley C. Van Voorhis,Kayode K. Ojo,J. Stone Doggett,Dorothea Fiedler,Stefan Hecht +8 more
TL;DR: In this paper , photoswitchable azopyrazoles were used to target CDPK1 from Toxoplasma gondii, a kinase naturally susceptible to analog-sensitive kinase inhibitors due to its glycine gatekeeper residue.
Journal ArticleDOI
One Scaffold, Two Conformations: The Ring-Flip of the Messenger InsP8 Occurs under Cytosolic Conditions
TL;DR: Inositol poly-and pyrophosphates (InsPs and PP-InsPs) are central eukaryotic messengers and can exist in two distinct conformations, a canonical one with five phosphoryl groups in equatorial positions, and a flipped conformation with five axial substituents as discussed by the authors .
Posted ContentDOI
Pyrophosphoproteomics: extensive protein pyrophosphorylation revealed in human cell lines
Jeremy A. M. Morgan,Arpita Singh,Leonie Kurz,Michal Nadler-Holly,Martin Penkert,Eberhard Krause,Fan Liu,Rashna Bhandari,Dorothea Fiedler +8 more
TL;DR: In this paper , a tailored pyrophosphoproteomics workflow was used to detect and reliably assign protein pyrophophosphorylation in two human cell lines, providing the first direct evidence of endogenous protein pyophosphoric activation.