D
Dorothea Fiedler
Researcher at Humboldt University of Berlin
Publications - 98
Citations - 5794
Dorothea Fiedler is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Inositol & Kinase. The author has an hindex of 33, co-authored 85 publications receiving 5000 citations. Previous affiliations of Dorothea Fiedler include University of California, San Francisco & Howard Hughes Medical Institute.
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Journal ArticleDOI
Inositol pyrophosphates promote the interaction of SPX domains with the coiled-coil motif of PHR transcription factors to regulate plant phosphate homeostasis
Martina Katharina Ried,Rebekka Wild,Jinsheng Zhu,Joka Pipercevic,Kristina Sturm,Larissa Broger,Robert K. Harmel,Luciano A. Abriata,Ludwig A. Hothorn,Dorothea Fiedler,Sebastian Hiller,Michael Hothorn +11 more
TL;DR: In this article, a PP-InsP-bound SPX receptors inactivate Myb coiled-coil (myb-CC) Pi starvation response transcription factors (PHRs) by an unknown mechanism.
Journal ArticleDOI
Inositol polyphosphates intersect with signaling and metabolic networks via two distinct mechanisms
Mingxuan Wu,Lucy Chong,Lucy Chong,David H. Perlman,Adam C. Resnick,Dorothea Fiedler,Dorothea Fiedler +6 more
TL;DR: These findings not only demonstrate that the PP-InsPs provide a central line of communication between signaling and metabolic networks, but also highlight the unusual ability of these molecules to access two distinct modes of action.
Journal ArticleDOI
Encapsulation of cationic ruthenium complexes into a chiral self-assembled cage.
TL;DR: Encapsulation of the prochiral complex [CpRu(p-cymene)](+) by the chiral host renders enantiotopic protons diastereotopic as evidenced by (1)H NMR spectroscopy.
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Analysis of inositol phosphate metabolism by capillary electrophoresis electrospray ionization mass spectrometry.
Danye Qiu,Miranda S. C. Wilson,Verena B. Eisenbeis,Robert K. Harmel,Esther Riemer,Thomas M. Haas,Christopher Wittwer,Nikolaus Jork,Chunfang Gu,Stephen B. Shears,Gabriel Schaaf,Bernd Kammerer,Dorothea Fiedler,Adolfo Saiardi,Henning J. Jessen +14 more
TL;DR: Capillary electrophoresis coupled to electrospray ionization mass spectrometry (ESI-MS) is implemented to analyze complex mixtures of InsPs and PP-InsPs with high sensitivity, providing evidence for the existence of unknown inositol synthesis pathways in mammals and highlighting the potential of this method to dissect inositl phosphate metabolism and signalling.
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Synthesis and characterization of non-hydrolysable diphosphoinositol polyphosphate messengers
TL;DR: The expedient synthesis of methylene-bisphosphonate PP-IP analogues is described, which revealed that the analogues exhibit significant stability and mimic their natural counterparts very well.