Dorothee Kretschmer

TL;DR: A previously uncharacterized set of S. aureus virulence factors are revealed that account at least in part for the enhanced virulence of CA-MRSA.

TL;DR: It is demonstrated that the human formyl peptide receptor 2 (FPR2/ALX), which has previously been implicated in control of endogenous inflammatory processes, senses PSMs at nanomolar concentrations and initiates proinflammatory neutrophil responses to CA-MRSA.

TL;DR: A previously unidentified psm gene, psm-mec, is described within the staphylococcal methicillin resistance-encoding MGE SCCmec and shows that important virulence and antibiotic resistance determinants may be combined in staphlyococcal MGEs.

TL;DR: It is clear that the activation of FPRs has more complex consequences and can also promote the resolution of inflammation.

TL;DR: It is shown that strong TLR2 stimulation depends on high-level production of phenol-soluble modulin (PSM) peptides in response to the global virulence activator Agr.