Douglas R. Pauley

TL;DR: The intestine appears to be a major target for SIV replication and the major site of CD4+ T cell loss in early SIV infection.

TL;DR: It is demonstrated that encephalitic brain from SIV-infected animals has elevated immunohistochemical expression of the C-C chemokines, macrophage inflammatory protein-1 alpha and -beta, RANTES, and monocyte chemotactic protein-3, and theC-X-C Chemokine interferon-inducible protein-10, suggesting that one or all of these chemokine could be involved in leukocyte recruitment to the brain

TL;DR: Findings provide evidence suggesting that neuroinvasion occurs through an influx of infected monocytes which take up residence in the CNS as perivascular macrophages/microglia, as well as confirming the role of VCAM-1 expression in this event.

TL;DR: It is suggested that VCAM-1 and VLA-4 may be integral for monocyte recruitment to the central nervous system during the development of AIDS encephalitis.

TL;DR: It is demonstrated that GALT of rhesus macaques is remarkably similar to that of humans, further justifying the use of these animals as models for various intestinal disorders.