W
Walter Newman
Researcher at Millennium Pharmaceuticals
Publications - 69
Citations - 12244
Walter Newman is an academic researcher from Millennium Pharmaceuticals. The author has contributed to research in topics: Chemokine & Eotaxin. The author has an hindex of 31, co-authored 66 publications receiving 11998 citations. Previous affiliations of Walter Newman include Yeshiva University & Takeda Pharmaceutical Company.
Papers
More filters
Journal ArticleDOI
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Hyeryun Choe,Michael Farzan,Ying Sun,Nancy Sullivan,Barrett J. Rollins,Paul D. Ponath,Lijun Wu,Charles R. Mackay,Gregory J. LaRosa,Walter Newman,Norma P. Gerard,Craig Gerard,Joseph Sodroski +12 more
TL;DR: The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV- 1 isolates.
Journal ArticleDOI
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
Lijun Wu,Norma P. Gerard,Richard T. Wyatt,Hyeryun Choe,Cristina Parolin,Nancy Ruffing,Alessândra Borsetti,Angelo A. Cardoso,Elizabeth Desjardin,Walter Newman,Craig Gerard,Joseph Sodroski +11 more
TL;DR: It is suggested that HIV-1 attachment to CD4 creates a high-affinity binding site for CCR-5, leading to membrane fusion and virus entry.
Journal ArticleDOI
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
Jianglin He,Youzhi Chen,Michael Farzan,Hyeryun Choe,Asa Ohagen,Suzanne Gartner,Jorge Busciglio,Jorge Busciglio,Xiaoyu Yang,Wolfgang Hofmann,Walter Newman,Charles R. Mackay,Joseph Sodroski,Dana Gabuzda +13 more
TL;DR: The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as did MIP-1β, which is a CCR5 ligand that promotes efficient infection of the CNS by HIV- 1.
Journal Article
IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1.
Robert P. Schleimer,Sherry A. Sterbinsky,James Kaiser,Carol A. Bickel,David Klunk,Kenichi Tomioka,Walter Newman,Francis W. Luscinskas,Michael A. Gimbrone,Bradley W. McIntyre +9 more
TL;DR: It is proposed that local release of IL-4 in vivo in allergic diseases or after experimental allergen challenge may partly explain the enrichment of eosinophils and basophils (vs neutrophils) observed in these situations.
Journal ArticleDOI
CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro
Lijun Wu,William A. Paxton,Nasim Kassam,Nancy Ruffing,James B. Rottman,Nancy Sullivan,Hyeryun Choe,Joseph Sodroski,Walter Newman,Richard A. Koup,Charles R. Mackay +10 more
TL;DR: Anti-CCR5 mAbs were poor inhibitors of chemokine binding, indicating that HIV-1 and ligands bind to separate, but overlapping regions of CCR5, and demonstrate the feasibility of blocking macrophage-tropic HIV- 1 entry into cells with an anti-CCr5 reagent.