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Douglas Simon Campbell
Researcher at University of Utah
Publications - 11
Citations - 3708
Douglas Simon Campbell is an academic researcher from University of Utah. The author has contributed to research in topics: Growth cone & Retinal ganglion. The author has an hindex of 10, co-authored 11 publications receiving 3398 citations. Previous affiliations of Douglas Simon Campbell include RIKEN Brain Science Institute & University of Cambridge.
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The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs.
Kristen M. Kwan,Esther Fujimoto,Clemens Grabher,Benjamin D. Mangum,Melissa Hardy,Douglas Simon Campbell,John M. Parant,H. Joseph Yost,John P. Kanki,Chi Bin Chien +9 more
TL;DR: The Tol2kit greatly facilitates zebrafish transgenesis, simplifies the sharing of clones, and enables large‐scale projects testing the functions of libraries of regulatory or coding sequences.
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Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation
TL;DR: The results suggest that guidance molecules steer axon growth by triggering rapid local changes in protein levels in growth cones by activating translation initiation factors and stimulating a marked rise in protein synthesis within minutes, while netrin-1 and LPA elicit similar rises in ubiquitin-protein conjugates.
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Axonal Protein Synthesis and Degradation Are Necessary for Efficient Growth Cone Regeneration
Poonam Verma,Sabrina Chierzi,Amanda M. Codd,Douglas Simon Campbell,Ronald L. Meyer,Christine E. Holt,James W. Fawcett +6 more
TL;DR: Findings suggest that local protein synthesis and degradation, controlled by various TOR-, p38 MAPK-, and caspase-dependent pathways, underlie growth cone initiation after axotomy.
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Apoptotic Pathway and MAPKs Differentially Regulate Chemotropic Responses of Retinal Growth Cones
TL;DR: It is reported that caspase-3, an apoptotic protease, is rapidly activated by netrin-1 and LPA in a proteasome- and p38-dependent manner and is required for chemotropic responses and translation.
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Semaphorin 3A elicits stage-dependent collapse, turning, and branching in Xenopus retinal growth cones.
Douglas Simon Campbell,Aoife G. Regan,Juanita S. Lopez,David Tannahill,William A. Harris,Christine E. Holt +5 more
TL;DR: It is shown that growth cones acquire responsiveness to semaphorin 3A (Sema 3A) with age and that the onset of responsiveness correlates with the appearance ofNP-1 immunoreactivity, suggesting that an intrinsic mechanism of NP-1 regulation mediates this age-dependent change.