C
Christine E. Holt
Researcher at University of Cambridge
Publications - 162
Citations - 20086
Christine E. Holt is an academic researcher from University of Cambridge. The author has contributed to research in topics: Growth cone & Axon guidance. The author has an hindex of 69, co-authored 158 publications receiving 18284 citations. Previous affiliations of Christine E. Holt include Institute of Medical Science & University of California, San Diego.
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Journal ArticleDOI
A critical window for cooperation and competition among developing retinotectal synapses
TL;DR: Both the initial synaptic strength and the temporal order of activation are critical for heterosynaptic interactions among convergent synaptic inputs during activity-dependent refinement of developing neural networks.
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Chemotropic Responses of Retinal Growth Cones Mediated by Rapid Local Protein Synthesis and Degradation
TL;DR: The results suggest that guidance molecules steer axon growth by triggering rapid local changes in protein levels in growth cones by activating translation initiation factors and stimulating a marked rise in protein synthesis within minutes, while netrin-1 and LPA elicit similar rises in ubiquitin-protein conjugates.
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ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function
Tetsuro Murakami,Seema Qamar,Julie Qiaojin Lin,Gabriele S. Kaminski Schierle,Eric J. Rees,Akinori Miyashita,Ana Rita Costa,Roger B. Dodd,Fiona T. S. Chan,Claire H. Michel,Deborah Kronenberg-Versteeg,Yi Li,Seung-Pil Yang,Yosuke Wakutani,William Meadows,Rodylyn Rose Ferry,Liang Dong,Gian Gaetano Tartaglia,Gian Gaetano Tartaglia,Giorgio Favrin,Wen-Lang Lin,Dennis W. Dickson,Mei Zhen,David Ron,Gerold Schmitt-Ulms,Paul E. Fraser,Neil A. Shneider,Christine E. Holt,Michele Vendruscolo,Clemens F. Kaminski,Peter St George-Hyslop,Peter St George-Hyslop +31 more
TL;DR: A model in which low-complexity (LC) domains of FUS drive its physiologically reversible assembly into membrane-free, liquid droplet and hydrogel-like structures mitigates neurotoxicity is proposed and suggests a potential therapeutic strategy that may also be applicable to ALS/FTD associated with mutations in other RNA binding proteins.
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FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
Seema Qamar,GuoZhen Wang,Suzanne J. Randle,Francesco Simone Ruggeri,Juan A. Varela,Julie Qiaojin Lin,Emma C. Phillips,Akinori Miyashita,Declan Williams,Florian Ströhl,William Meadows,Rodylyn Rose Ferry,Victoria Dardov,Gian Gaetano Tartaglia,Gian Gaetano Tartaglia,Lindsay A. Farrer,Gabriele S. Kaminski Schierle,Clemens F. Kaminski,Christine E. Holt,Paul E. Fraser,Gerold Schmitt-Ulms,David Klenerman,Tuomas P. J. Knowles,Michele Vendruscolo,Peter St George-Hyslop,Peter St George-Hyslop +25 more
TL;DR: It is reported that cooperative cation-π interactions between tyrosines in the LC domain and arginines in structured C-terminal domains also contribute to phase separation, and transportin acts as a physiological molecular chaperone of FUS in neuron terminals, reducing phase separation and gelation of methylated and hypomethylated FUS and rescuing protein synthesis.
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Cellular determination in the xenopus retina is independent of lineage and birth date
TL;DR: A scheme for cellular determination in the Xenopus retina is presented in which a coherent group of clonally related cells stretch out radially as lamination begins, which brings different cells into different microenvironments.