D
Douglas W. Jones
Researcher at National Institutes of Health
Publications - 62
Citations - 5495
Douglas W. Jones is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Serotonin & Muscarinic acetylcholine receptor. The author has an hindex of 35, co-authored 62 publications receiving 5364 citations. Previous affiliations of Douglas W. Jones include Stanley Foundation & University of Hamburg.
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Journal ArticleDOI
Genotype Influences In Vivo Dopamine Transporter Availability in Human Striatum
Andreas Heinz,David Goldman,Douglas W. Jones,Roberta Palmour,Dan Hommer,Julia G. Gorey,Kan S. Lee,Markku Linnoila,Daniel R. Weinberger +8 more
TL;DR: It is suggested that the VNTR polymorphism of the DAT gene effects translation of theDAT protein, which may explain a variety of clinical associations that have been reported with this polymorphism.
Journal ArticleDOI
A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity.
Andreas Heinz,Douglas W. Jones,C.M. Mazzanti,David Goldman,Paul W Ragan,Dan Hommer,Markku Linnoila,Daniel R. Weinberger +7 more
TL;DR: Preliminary findings suggest an association between 5-HTT allelic constitution and in vivo measurements of human serotonin transporter availability, and a potentially selective susceptibility of ll-homozygous individuals to the neurotoxic effects of chronic excessive alcohol consumption.
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Genetic variability of human brain size and cortical gyral patterns.
TL;DR: The results indicate that human cerebral size is determined almost entirely by genetic factors and that overall cortical gyral patterns, though significantly affected by genes, are determined primarily by nongenetic factors.
Journal ArticleDOI
Reduced Central Serotonin Transporters in Alcoholism
Andreas Heinz,Paul W Ragan,Douglas W. Jones,Dan Hommer,Wendol Williams,Michael B. Knable,Julia G. Gorey,Linda Doty,Christopher Geyer,Kan S. Lee,Richard Coppola,Daniel R. Weinberger,Markku Linnoila +12 more
TL;DR: The hypothesis of serotonergic dysfunction in alcoholism and in withdrawal-emergent depressive symptoms is supported, which was significantly correlated with lifetime alcohol consumption and with ratings of depression and anxiety during withdrawal.
Journal ArticleDOI
The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia.
David G. Daniel,Daniel R. Weinberger,Douglas W. Jones,Jeffrey Fl Zigun,Richard Coppola,Sharon Handel,Llewellyn B. Bigelow,Terry E. Goldberg,Karen F. Berman,Joel E. Kleinman +9 more
TL;DR: Findings are consistent with animal models in which mesocortical catecholaminergic activity modulates and enhances the signal-to-noise ratio of evoked cortical activity.