Du Chu Wu

TL;DR: It is shown that minocycline, an approved tetracycline derivative that inhibits microglial activation independently of its antimicrobial properties, mitigates both the demise of nigrostriatal dopaminergic neurons and the formation of nitrotyrosine produced by MPTP.

TL;DR: It is found that minocycline inhibits mitochondrial permeability-transition-mediated cytochrome c release, and this drug may be a novel therapy for ALS.

TL;DR: It is proposed that dopamine-induced autophagic inhibition could explain the selective degeneration of PD dopaminergic neurons through blockage of CMA, which increases cellular vulnerability to stressors.

TL;DR: The potential protective and deleterious effects of glial cells in the substantia nigra pars compacta of Parkinson's disease are reviewed.

TL;DR: It is demonstrated that myeloperoxidase (MPO), a key oxidant-producing enzyme during inflammation, is upregulated in the ventral midbrain of human PD and MPTP mice and suggested that inhibitors of MPO may provide a protective benefit in PD.