D
Duncan Wilson
Researcher at University of Aberdeen
Publications - 72
Citations - 5008
Duncan Wilson is an academic researcher from University of Aberdeen. The author has contributed to research in topics: Candida albicans & Corpus albicans. The author has an hindex of 27, co-authored 67 publications receiving 4108 citations. Previous affiliations of Duncan Wilson include University of Exeter & Leibniz Association.
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Journal ArticleDOI
Candida albicans pathogenicity mechanisms
TL;DR: This review presents an update on the current understanding of the pathogenicity mechanisms of this important human pathogen and reveals novel virulence mechanisms have recently been discovered.
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Candidalysin is a fungal peptide toxin critical for mucosal infection
David L. Moyes,Duncan Wilson,Jonathan P. Richardson,Selene Mogavero,Shirley X. Tang,Julia Wernecke,Sarah Höfs,Remi L. Gratacap,Jon Robbins,Manohursingh Runglall,Celia Murciano,Mariana Blagojevic,Selvam Thavaraj,Toni M. Förster,Betty Hebecker,Lydia Kasper,Gema Vizcay,Simona Ioana Iancu,Nessim Kichik,Nessim Kichik,Antje Häder,Oliver Kurzai,Ting Luo,Thomas Krüger,Olaf Kniemeyer,Ernesto Cota,Oliver Bader,Robert T. Wheeler,Thomas Gutsmann,Bernhard Hube,Julian R. Naglik +30 more
TL;DR: A fungal cytolytic peptide toxin in the opportunistic pathogen Candida albicans was identified in this article, which directly damages epithelial membranes, triggers a danger response signalling pathway and activates epithelial immunity.
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Cellular interactions of Candida albicans with human oral epithelial cells and enterocytes.
Frédéric Dalle,Betty Wächtler,Betty Wächtler,C. L’Ollivier,Gudrun Holland,Norbert Bannert,Duncan Wilson,Catherine Labruère,Alain Bonnin,Bernhard Hube,Bernhard Hube,Bernhard Hube +11 more
TL;DR: This study uses scanning electron and fluorescence microscopy, adhesion, invasion and damage assays, fungal mutants and a set of fungal and host cell inhibitors to investigate the interactions of C. albicans with oral epithelial cells and enterocytes, demonstrating that epithelial Cells differ in their susceptibility to the fungus.
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Candida albicans dimorphism as a therapeutic target
TL;DR: An overview of the known and potential roles of C. albicans dimorphism is provided and the potential benefit of drugs that can inhibit the morphological transition is discussed.
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From attachment to damage: defined genes of Candida albicans mediate adhesion, invasion and damage during interaction with oral epithelial cells.
TL;DR: The data support a model whereby initial epithelial invasion per se does not elicit host damage, but that C. albicans relies on a combination of contact-sensing, directed hyphal extension, active penetration and the expression of novel pathogenicity factors for further inter-epithelial invasion, dissemination and ultimate damage of host cells.