D
David L. Moyes
Researcher at King's College London
Publications - 88
Citations - 4822
David L. Moyes is an academic researcher from King's College London. The author has contributed to research in topics: Candida albicans & Candidalysin. The author has an hindex of 32, co-authored 74 publications receiving 3986 citations. Previous affiliations of David L. Moyes include Imperial College London & Hammersmith Hospital.
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Journal ArticleDOI
Candidalysin is a fungal peptide toxin critical for mucosal infection
David L. Moyes,Duncan Wilson,Jonathan P. Richardson,Selene Mogavero,Shirley X. Tang,Julia Wernecke,Sarah Höfs,Remi L. Gratacap,Jon Robbins,Manohursingh Runglall,Celia Murciano,Mariana Blagojevic,Selvam Thavaraj,Toni M. Förster,Betty Hebecker,Lydia Kasper,Gema Vizcay,Simona Ioana Iancu,Nessim Kichik,Nessim Kichik,Antje Häder,Oliver Kurzai,Ting Luo,Thomas Krüger,Olaf Kniemeyer,Ernesto Cota,Oliver Bader,Robert T. Wheeler,Thomas Gutsmann,Bernhard Hube,Julian R. Naglik +30 more
TL;DR: A fungal cytolytic peptide toxin in the opportunistic pathogen Candida albicans was identified in this article, which directly damages epithelial membranes, triggers a danger response signalling pathway and activates epithelial immunity.
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Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis.
Andrew J Kinloch,Verena Tatzer,Robin Wait,David Peston,Karin Lundberg,Phillipe Donatien,David L. Moyes,Peter C. Taylor,Patrick J Venables +8 more
TL;DR: The presence of antibody together with expression of antigen within the joint implicates citrullinated α-enolase as a candidate autoantigen that could drive the chronic inflammatory response in RA.
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A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells
David L. Moyes,Manohursingh Runglall,Celia Murciano,Chengguo Shen,Deepa Nayar,Selvam Thavaraj,Arinder Kohli,Ayesha Islam,Héctor M. Mora-Montes,Stephen Challacombe,Julian R. Naglik +10 more
TL;DR: It is demonstrated that oral epithelial cells orchestrate an innate response to C. albicans via NF-κB and a biphasic MAPK response, which may allow epithelial tissues to remain quiescent under low fungal burdens while responding specifically and strongly to damage-inducing hyphae when burdens increase.
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Candida albicans interactions with epithelial cells and mucosal immunity.
TL;DR: This review will outline the current understanding of C. albicans-epithelial interactions and will discuss how this may lead to the induction of a protective mucosal immune response.
Journal ArticleDOI
Quantitative expression of the Candida albicans secreted aspartyl proteinase gene family in human oral and vaginal candidiasis
Julian R. Naglik,David L. Moyes,Jagruti Makwana,Priya Kanzaria,Elina Tsichlaki,Günther Weindl,Anwar R. Tappuni,Catherine A. Rodgers,Alexander J. Woodman,Stephen Challacombe,Martin Schaller,Bernhard Hube +11 more
TL;DR: Results suggest that SAP5 and SAP9 are the most highly expressed proteinase genes in vivo, however, the overall contribution of the Sap1-3 and Sap4-6 subfamilies individually in inducing epithelial damage in the RHE models appears to be low.