J
Julian R. Naglik
Researcher at King's College London
Publications - 111
Citations - 9047
Julian R. Naglik is an academic researcher from King's College London. The author has contributed to research in topics: Candida albicans & Corpus albicans. The author has an hindex of 43, co-authored 100 publications receiving 7479 citations. Previous affiliations of Julian R. Naglik include Guy's Hospital.
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Journal ArticleDOI
Candida albicans Secreted Aspartyl Proteinases in Virulence and Pathogenesis
TL;DR: Critically discussed the data relevant to each of these seven criteria, with specific emphasis on how this proteinase family could contribute to Candida virulence and pathogenesis.
Journal ArticleDOI
Candidalysin is a fungal peptide toxin critical for mucosal infection
David L. Moyes,Duncan Wilson,Jonathan P. Richardson,Selene Mogavero,Shirley X. Tang,Julia Wernecke,Sarah Höfs,Remi L. Gratacap,Jon Robbins,Manohursingh Runglall,Celia Murciano,Mariana Blagojevic,Selvam Thavaraj,Toni M. Förster,Betty Hebecker,Lydia Kasper,Gema Vizcay,Simona Ioana Iancu,Nessim Kichik,Nessim Kichik,Antje Häder,Oliver Kurzai,Ting Luo,Thomas Krüger,Olaf Kniemeyer,Ernesto Cota,Oliver Bader,Robert T. Wheeler,Thomas Gutsmann,Bernhard Hube,Julian R. Naglik +30 more
TL;DR: A fungal cytolytic peptide toxin in the opportunistic pathogen Candida albicans was identified in this article, which directly damages epithelial membranes, triggers a danger response signalling pathway and activates epithelial immunity.
Journal ArticleDOI
Fungal Adenylyl Cyclase Integrates CO2 Sensing with cAMP Signaling and Virulence
Torsten Klengel,Wei-Jun Liang,James Chaloupka,Claudia Ruoff,Klaus Schröppel,Julian R. Naglik,Sabine E. Eckert,Estelle Gewiss Mogensen,Ken Haynes,Mick F. Tuite,Lonny R. Levin,Jochen Buck,Fritz A. Mühlschlegel +12 more
TL;DR: It is demonstrated that physiological concentrations of CO2/HCO3- induce filamentation in C. albicans by direct stimulation of cyclase activity and revealed CO2 sensing to be an important mediator of fungal pathogenesis.
Journal ArticleDOI
Candida albicans proteinases and host/pathogen interactions.
TL;DR: The aim of this review is to explore the functional roles of the C. albicans proteinases and how they may contribute to the host/pathogen interaction in vivo.
Journal ArticleDOI
A Biphasic Innate Immune MAPK Response Discriminates between the Yeast and Hyphal Forms of Candida albicans in Epithelial Cells
David L. Moyes,Manohursingh Runglall,Celia Murciano,Chengguo Shen,Deepa Nayar,Selvam Thavaraj,Arinder Kohli,Ayesha Islam,Héctor M. Mora-Montes,Stephen Challacombe,Julian R. Naglik +10 more
TL;DR: It is demonstrated that oral epithelial cells orchestrate an innate response to C. albicans via NF-κB and a biphasic MAPK response, which may allow epithelial tissues to remain quiescent under low fungal burdens while responding specifically and strongly to damage-inducing hyphae when burdens increase.