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Robert T. Wheeler
Researcher at University of Maine
Publications - 59
Citations - 5241
Robert T. Wheeler is an academic researcher from University of Maine. The author has contributed to research in topics: Candida albicans & Immune system. The author has an hindex of 29, co-authored 56 publications receiving 4387 citations. Previous affiliations of Robert T. Wheeler include Stanford University & University of California, San Diego.
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Journal ArticleDOI
Regulation of progenitor cell proliferation and granulocyte function by microRNA-223
Jonathan B. Johnnidis,Marian H. Harris,Robert T. Wheeler,Sandra Stehling-Sun,Michael H. Lam,Oktay Kirak,Thijn R. Brummelkamp,Mark D. Fleming,Fernando D. Camargo +8 more
TL;DR: It is reported here that the myeloid-specific microRNA-223 (miR-223) negatively regulates progenitor proliferation and granulocyte differentiation and activation and that genetic ablation of Mef2c suppresses progenitors expansion and corrects the neutrophilic phenotype in miR- 223 null mice.
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Candidalysin is a fungal peptide toxin critical for mucosal infection
David L. Moyes,Duncan Wilson,Jonathan P. Richardson,Selene Mogavero,Shirley X. Tang,Julia Wernecke,Sarah Höfs,Remi L. Gratacap,Jon Robbins,Manohursingh Runglall,Celia Murciano,Mariana Blagojevic,Selvam Thavaraj,Toni M. Förster,Betty Hebecker,Lydia Kasper,Gema Vizcay,Simona Ioana Iancu,Nessim Kichik,Nessim Kichik,Antje Häder,Oliver Kurzai,Ting Luo,Thomas Krüger,Olaf Kniemeyer,Ernesto Cota,Oliver Bader,Robert T. Wheeler,Thomas Gutsmann,Bernhard Hube,Julian R. Naglik +30 more
TL;DR: A fungal cytolytic peptide toxin in the opportunistic pathogen Candida albicans was identified in this article, which directly damages epithelial membranes, triggers a danger response signalling pathway and activates epithelial immunity.
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A drug-sensitive genetic network masks fungi from the immune system.
Robert T. Wheeler,Gerald R. Fink +1 more
TL;DR: It is found that the underlying β-glucan in the cell wall of Candida albicans is unmasked by subinhibitory doses of the antifungal drug caspofungin, causing the exposed fungi to elicit a stronger immune response.
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Dynamic, Morphotype-Specific Candida albicans β-Glucan Exposure during Infection and Drug Treatment
TL;DR: It is shown that during infection of mice, the C. albicans β-glucan is masked initially but becomes exposed later in several organs, and Surprisingly, caspofungin preferentially unmasks filamentous cells, as opposed to yeast form cells, both in vivo and in vitro.
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Differential Localization of Two Histidine Kinases Controlling Bacterial Cell Differentiation
Robert T. Wheeler,Lucy Shapiro +1 more
TL;DR: It is demonstrated that the antagonistic DivJ and PleC histidine kinases that regulate polar differentiation are differentially localized as a function of the cell cycle.