D
D G R Evans
Researcher at St Mary's Hospital
Publications - 16
Citations - 6757
D G R Evans is an academic researcher from St Mary's Hospital. The author has contributed to research in topics: Neurofibromatosis & Cancer. The author has an hindex of 14, co-authored 16 publications receiving 6173 citations.
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Journal ArticleDOI
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies
Antonis C. Antoniou,Paul D.P. Pharoah,Steven A. Narod,Harvey A. Risch,Jorunn E. Eyfjord,John L. Hopper,Niklas Loman,Håkan Olsson,Oskar T. Johannsson,Åke Borg,Barbara Pasini,Paolo Radice,Siranoush Manoukian,Diana Eccles,Nelson L.S. Tang,E. Olah,Hoda Anton-Culver,Ellen Warner,Jan Lubinski,Jacek Gronwald,Bohdan Górski,Hrafn Tulinius,Steinunn Thorlacius,Hannaleena Eerola,Heli Nevanlinna,Kirsi Syrjäkoski,Olli Kallioniemi,Deborah J. Thompson,Christopher H. Evans,Julian Peto,Julian Peto,Fiona Lalloo,D G R Evans,Douglas F. Easton +33 more
TL;DR: Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age and for variation in risk by mutation position for both genes, and some evidence for a reduction in risk in women from earlier birth cohorts is found.
Journal ArticleDOI
Malignant peripheral nerve sheath tumours in neurofibromatosis 1
TL;DR: The lifetime risk of MPNST in NF1 is much higher than previously estimated and warrants careful surveillance and a low threshold for investigation.
Journal ArticleDOI
Birth incidence and prevalence of tumor-prone syndromes: estimates from a UK family genetic register service.
D G R Evans,E. Howard,E. Howard,C. Giblin,C. Giblin,Thomas E. Clancy,Thomas E. Clancy,H. Spencer,H. Spencer,Susan M Huson,Susan M Huson,Fiona Lalloo,Fiona Lalloo +12 more
TL;DR: Estimates for NF1, NF2, FAP, and VHL are in line with previous estimates, and the first estimates of birth incidence and de novo mutation rate for Gorlin syndrome are provided.
Journal ArticleDOI
Diagnostic criteria for schwannomatosis
Mia MacCollin,E A Chiocca,D G R Evans,Jan M. Friedman,R. Horvitz,Diego Jaramillo,Michael H. Lev,V. F. Mautner,M. Niimura,Scott R. Plotkin,Christine N. Sang,Anat Stemmer-Rachamimov,E. S. Roach +12 more
TL;DR: Diagnostic criteria for schwannomatosis are needed for both clinicians and researchers, but final diagnostic certainly will await the identification of the schWannom atosis locus itself.
Journal ArticleDOI
An absence of cutaneous neurofibromas associated with a 3-bp inframe deletion in Exon 17 of the NF1 gene (c.2970-2972 delAAT): evidence of a clinically significant NF1 genotype-phenotype correlation
Meena Upadhyaya,Susan M Huson,M. Davies,Nicholas Stuart Tudor Thomas,Nadia Chuzhanova,S. Giovannini,D G R Evans,E. Howard,Bronwyn Kerr,Sian Wyn Griffiths,Claudia Consoli,Lucy Side,Darius J. Adams,Mary Ella M Pierpont,Rachel K. Hachen,A. Barnicoat,Hua Li,P. Wallace,J. P. Van Biervliet,David A. Stevenson,Dave Viskochil,Diana Baralle,Eric Haan,Vincent M. Riccardi,Peter D. Turnpenny,Conxi Lázaro,Ludwine Messiaen +26 more
TL;DR: These data represent results from the first study to correlate a specific small mutation of the NF1 gene to the expression of a particular clinical phenotype, and the biological mechanism that relates this specific mutation to the suppression of cutaneous neurofibroma development is unknown.