E
E. Kenneth Weir
Researcher at University of Minnesota
Publications - 88
Citations - 7001
E. Kenneth Weir is an academic researcher from University of Minnesota. The author has contributed to research in topics: Pulmonary hypertension & Hypoxic pulmonary vasoconstriction. The author has an hindex of 35, co-authored 86 publications receiving 6234 citations. Previous affiliations of E. Kenneth Weir include Veterans Health Administration & University of Giessen.
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Journal ArticleDOI
Cellular and molecular pathobiology of pulmonary arterial hypertension.
Marc Humbert,Nicholas W. Morrell,Stephen L. Archer,Kurt R. Stenmark,Margaret R. MacLean,Irene M. Lang,Brian W. Christman,E. Kenneth Weir,Oliver Eickelberg,Norbert F. Voelkel,Marlene Rabinovitch +10 more
TL;DR: Pulmonary arterial hypertension has a multifactorial pathobiology and recent genetic and pathophysiologic studies have emphasized the relevance of several mediators in this condition, including prostacyclin, nitric oxide, ET-1, angiopoietin- 1, serotonin, cytokines, chemokines, and members of the transforming-growth-factor-beta superfamily.
Journal ArticleDOI
Cellular and molecular basis of pulmonary arterial hypertension.
Nicholas W. Morrell,Serge Adnot,Stephen L. Archer,Jocelyn Dupuis,Peter L. Jones,Margaret R. MacLean,Ivan F. McMurtry,Kurt R. Stenmark,Patricia A. Thistlethwaite,Norbert Weissmann,Jason X.-J. Yuan,E. Kenneth Weir +11 more
TL;DR: The origins of a cell type critical to the process of pulmonary vascular remodeling, the myofibroblast, are discussed, and the evidence supporting a contribution for the involvement of endothelial-mesenchymal transition and recruitment of circulating mesenchymic progenitor cells is reviewed.
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Basic Science of Pulmonary Arterial Hypertension for Clinicians New Concepts and Experimental Therapies
TL;DR: Although increased afterload initiates RV failure, which is the major cause of death/dysfunction in PAH, the RV may be amenable to cardiac-targeted therapies and targeted therapeutically.
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Acute Oxygen-Sensing Mechanisms
TL;DR: This review discusses recent advances in the understanding of the ways in which different organs detect and respond to acute changes in oxygen tension.
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Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension
Glenn Marsboom,Peter T. Toth,John J. Ryan,Zhigang Hong,Xichen Wu,Yong Hu Fang,Thenappan Thenappan,Lin Piao,Hannah J. Zhang,Jennifer Pogoriler,Yimei Chen,Erik Morrow,E. Kenneth Weir,Jalees Rehman,Stephen L. Archer +14 more
TL;DR: DRP-1–mediated mitotic fission is a cell-cycle checkpoint that can be therapeutically targeted in hyperproliferative disorders such as PAH and may slow proliferation and have therapeutic potential.