G
Glenn Marsboom
Researcher at University of Illinois at Chicago
Publications - 40
Citations - 3484
Glenn Marsboom is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Endothelial stem cell & Progenitor cell. The author has an hindex of 24, co-authored 40 publications receiving 2990 citations. Previous affiliations of Glenn Marsboom include Flanders Institute for Biotechnology & University of Chicago.
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Journal ArticleDOI
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer
Jalees Rehman,Hannah J. Zhang,Peter T. Toth,Yanmin Zhang,Glenn Marsboom,Zhigang Hong,Ravi Salgia,Aliya N. Husain,Christian Wietholt,Stephen L. Archer +9 more
TL;DR: It is reported that human lung cancer cell lines exhibit an imbalance of Drp‐1/Mfn‐2 expression, which promotes a state of mitochondrial fission, which contributes fundamentally to the proliferation/apoptosis imbalance in cancer and constitute promising novel therapeutic targets.
Journal ArticleDOI
Dynamin-Related Protein 1–Mediated Mitochondrial Mitotic Fission Permits Hyperproliferation of Vascular Smooth Muscle Cells and Offers a Novel Therapeutic Target in Pulmonary Hypertension
Glenn Marsboom,Peter T. Toth,John J. Ryan,Zhigang Hong,Xichen Wu,Yong Hu Fang,Thenappan Thenappan,Lin Piao,Hannah J. Zhang,Jennifer Pogoriler,Yimei Chen,Erik Morrow,E. Kenneth Weir,Jalees Rehman,Stephen L. Archer +14 more
TL;DR: DRP-1–mediated mitotic fission is a cell-cycle checkpoint that can be therapeutically targeted in hyperproliferative disorders such as PAH and may slow proliferation and have therapeutic potential.
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The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle
Lin Piao,Yong Hu Fang,Virgilio J. J. Cadete,Christian Wietholt,Dalia Urboniene,Peter T. Toth,Glenn Marsboom,Hannah J. Zhang,Idith Haber,Jalees Rehman,Gary D. Lopaschuk,Stephen L. Archer +11 more
TL;DR: Reduction in RV function and electrical remodeling in two models of RVH relevant to human disease (PAH and pulmonic stenosis) result, in part, from a PDK-mediated glycolytic shift in the RV.
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Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells.
TL;DR: In this article, the authors investigated the role of metabolic shifts in the differentiation of human mesenchymal stem cells (MSCs) into adult multipotent stem cells and showed that increased mitochondrial activity is a prerequisite for MSC differentiation into adipocytes.
Journal ArticleDOI
BNip3 regulates mitochondrial function and lipid metabolism in the liver.
Danielle Glick,Wenshuo Zhang,Michelle Beaton,Glenn Marsboom,Michaela Gruber,M. Celeste Simon,John Hart,Gerald W. Dorn,Matthew J. Brady,Kay F. Macleod +9 more
TL;DR: A role for BNip3 is identified in limiting mitochondrial mass and maintaining mitochondrial integrity in the liver that has consequences for lipid metabolism and disease.