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Eduardo Tamayo
Researcher at University of Valladolid
Publications - 151
Citations - 2517
Eduardo Tamayo is an academic researcher from University of Valladolid. The author has contributed to research in topics: Sepsis & Septic shock. The author has an hindex of 23, co-authored 135 publications receiving 1842 citations.
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Journal ArticleDOI
Unsupervised analysis of transcriptomics in bacterial sepsis across multiple datasets reveals three robust clusters
Timothy E. Sweeney,Tej D. Azad,Michele Donato,Winston A. Haynes,Thanneer M. Perumal,Ricardo Henao,Jesus F. Bermejo-Martin,Raquel Almansa,Eduardo Tamayo,Judith A. Howrylak,Augustine M.K. Choi,Grant P Parnell,Benjamin Tang,Marshall Nichols,Christopher W. Woods,Christopher W. Woods,Geoffrey S. Ginsburg,Stephen F. Kingsmore,Larsson Omberg,Lara M. Mangravite,Hector R. Wong,Ephraim L. Tsalik,Ephraim L. Tsalik,Raymond J. Langley,Purvesh Khatri +24 more
TL;DR: A unified clustering analysis across 14 discovery datasets revealed three sepsis subtypes, which, based on functional analysis, were termed “Inflammopathic, Adaptive, and Coagulopathic,” which may represent a unifying framework for understanding the molecular heterogeneity of the sepsi syndrome.
Journal ArticleDOI
A community approach to mortality prediction in sepsis via gene expression analysis
Timothy E. Sweeney,Thanneer M. Perumal,Ricardo Henao,Marshall Nichols,Judie A. Howrylak,Augustine M.K. Choi,Jesus F. Bermejo-Martin,Raquel Almansa,Eduardo Tamayo,Emma E. Davenport,Katie L. Burnham,Charles J. Hinds,Julian C. Knight,Christopher W. Woods,Christopher W. Woods,Stephen F. Kingsmore,Geoffrey S. Ginsburg,Hector R. Wong,Grant P Parnell,Benjamin Tang,Lyle L. Moldawer,Frederick E. Moore,Larsson Omberg,Purvesh Khatri,Ephraim L. Tsalik,Ephraim L. Tsalik,Lara M. Mangravite,Raymond J. Langley +27 more
TL;DR: These models provide an opportunity to develop molecular bedside tests that may improve risk stratification and mortality prediction in patients with sepsis and lead to significant improvement in prediction of 30-day mortality as measured via AUROC and net reclassification improvement index.
Journal ArticleDOI
A combined score of pro- and anti-inflammatory interleukins improves mortality prediction in severe sepsis.
David Andaluz-Ojeda,Felipe Bobillo,Verónica Iglesias,Raquel Almansa,Lucia Rico,Francisco Gandía,Salvador Resino,Eduardo Tamayo,Raúl Ortiz de Lejarazu,Jesus F. Bermejo-Martin +9 more
TL;DR: A combined cytokine score associated with a worse outcome in patients with sepsis is described, which may represent a new avenue to be explored for guiding treatment decisions in this disease.
Journal ArticleDOI
Pro- and anti-inflammatory responses are regulated simultaneously from the first moments of septic shock
Eduardo Tamayo,Ana Fernández,Raquel Almansa,Elena Carrasco,María Heredia,Carmen Lajo,Lisbeth Goncalves,José Ignacio Gómez-Herreras,Raúl Ortiz de Lejarazu,Jesus F. Bermejo-Martin +9 more
TL;DR: The Spearman test demonstrated a positive association between the pro-inflammatory mediators IL-6, IL-8, MCP-1, MIP-1β, IFN-γ, GM-CSF and the immunomodulatory cytokine IL-10 in septic shock as discussed by the authors.
Journal ArticleDOI
Superior accuracy of mid-regional proadrenomedullin for mortality prediction in sepsis with varying levels of illness severity
David Andaluz-Ojeda,H. Bryant Nguyen,Nicolas Meunier-Beillard,Ramón Cicuendez,Jean-Pierre Quenot,Dolores Calvo,Auguste Dargent,Esther Zarca,C. Andres,Leonor Nogales,José María Eiros,Eduardo Tamayo,Francisco Gandía,Jesus F. Bermejo-Martin,Pierre Emmanuel Charles +14 more
TL;DR: The ability of mid-regional proadrenomedullin (MR-proADM) in predicting mortality in sepsis patients with different degrees of organ failure, compared to that of procalcitonin, C-reactive protein and lactate is examined.