G
Geoffrey S. Ginsburg
Researcher at Duke University
Publications - 371
Citations - 19599
Geoffrey S. Ginsburg is an academic researcher from Duke University. The author has contributed to research in topics: Health care & Personalized medicine. The author has an hindex of 66, co-authored 354 publications receiving 17111 citations. Previous affiliations of Geoffrey S. Ginsburg include Durham University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
A genomic strategy to refine prognosis in early-stage non-small-cell lung cancer.
Anil Potti,Sayan Mukherjee,Rebecca P. Petersen,Holly K. Dressman,Andrea Bild,Jason I. Koontz,Robert A. Kratzke,Mark A. Watson,Michael J. Kelley,Geoffrey S. Ginsburg,Mike West,David H. Harpole,Joseph R. Nevins +12 more
TL;DR: The lung metagene model provides a potential mechanism to refine the estimation of a patient's risk of disease recurrence and, in principle, to alter decisions regarding the use of adjuvant chemotherapy in early-stage NSCLC.
Journal ArticleDOI
The path to personalized medicine.
TL;DR: Research is leading to the identification of a range of molecular markers for predisposition testing, disease screening and prognostic assessment, as well as markers used to predict and monitor drug response.
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Genomic signatures to guide the use of chemotherapeutics.
Anil Potti,Holly K. Dressman,Andrea H. Bild,Richard F. Riedel,Gina Chan,Robyn Sayer,Janiel M. Cragun,Hope Cottrill,Michael J. Kelley,Rebecca P. Petersen,David H. Harpole,Jeffrey R. Marks,Andrew Berchuck,Geoffrey S. Ginsburg,Phillip G. Febbo,Johnathan M. Lancaster,Joseph R. Nevins +16 more
TL;DR: Using in vitro drug sensitivity data coupled with Affymetrix microarray data, gene expression signatures that predict sensitivity to individual chemotherapeutic drugs are developed that can accurately predict clinical response in individuals treated with these drugs.
Journal ArticleDOI
Genomic and personalized medicine: foundations and applications.
TL;DR: There are challenges from both a scientific and a policy perspective to personalized health care; however, they will be confronted and solved with the certainty that the science behind genomic medicine is sound and the practice of medicine that it informs is evidence based.
Journal ArticleDOI
Implementing genomic medicine in the clinic: the future is here
Teri A. Manolio,Rex L. Chisholm,Brad Ozenberger,Dan M. Roden,Marc S. Williams,Richard Trevor Wilson,David P. Bick,Erwin P. Bottinger,Murray H. Brilliant,Charis Eng,Kelly A. Frazer,Bruce R. Korf,David H. Ledbetter,James R. Lupski,Clay B. Marsh,David A. Mrazek,Michael F. Murray,Peter H. O'Donnell,Daniel J. Rader,Mary V. Relling,Alan R. Shuldiner,David Valle,Richard M. Weinshilboum,Eric D. Green,Geoffrey S. Ginsburg +24 more
TL;DR: The National Human Genome Research Institute brought together a number of institutions to describe their ongoing projects and challenges, identify common infrastructure and research needs, and outline an implementation framework for investigating and introducing similar programs elsewhere.