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Edward H. Birkenmeier
Researcher at Saint Louis University
Publications - 50
Citations - 5648
Edward H. Birkenmeier is an academic researcher from Saint Louis University. The author has contributed to research in topics: Mucopolysaccharidosis & Mucopolysaccharidosis VII. The author has an hindex of 34, co-authored 50 publications receiving 5537 citations.
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Mutations in a NIMA-related kinase gene, Nek1, cause pleiotropic effects including a progressive polycystic kidney disease in mice
TL;DR: The complex pleiotropic phenotypes seen in the homozygous mutant animals suggest that the NEK1 protein participates in different signaling pathways to regulate diverse cellular processes, and identifies a previously unsuspected role for Nek1 in the kidney.
Journal Article
Treatment of murine mucopolysaccharidosis type VII by syngeneic bone marrow transplantation in neonates.
Mark S. Sands,Jane E. Barker,Carole Vogler,Beth Levy,Babette Gwynn,Nancy Galvin,William S. Sly,Edward H. Birkenmeier +7 more
TL;DR: BMT is a more effective therapy for MPS VII when it is performed at birth rather than in adults, and alternate means of ablating host hematopoietic stem cells should be employed as a pretreatment for BMT due to the severe side effects of radiation on newborns.
Journal Article
Spontaneously colitic C3H/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora.
Steven L. Brandwein,Robert P. McCabe,Yingzi Cong,Ken B. Waites,B U Ridwan,Phillip A. Dean,Toshifumi Ohkusa,Edward H. Birkenmeier,John P. Sundberg,Charles O. Elson +9 more
TL;DR: Comparison of sera reactivity to histopathologic severity showed an inverse relationship: one third of young C3H/HeJBir mice during the peak of colitis produced Abs to bacterial Ags, while later in life, when the colitis had resolved, 96% produced Abs.
Journal Article
A murine model of mucopolysaccharidosis VII. Gross and microscopic findings in beta-glucuronidase-deficient mice.
Carole Vogler,Edward H. Birkenmeier,William S. Sly,Beth Levy,C. Pegors,J W Kyle,Wesley G. Beamer +6 more
TL;DR: These mice provide a well-defined genetic system for the analysis of the pathophysiology of mucopolysaccharidosis type VII, which has many features in common with the other MPS, and provide an attractive animal model to test potential therapies for lysosomal storage disease.
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Mechanisms underlying generation of gradients in gene expression within the intestine: an analysis using transgenic mice containing fatty acid binding protein-human growth hormone fusion genes.
TL;DR: In this article, the authors linked portions of the L-FABP gene's 5' nontranscribed region to the human growth hormone (hGH) gene and examined hGH expression in transgenic mice.