E
Egidio Stigliano
Researcher at Catholic University of the Sacred Heart
Publications - 60
Citations - 1884
Egidio Stigliano is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor. The author has an hindex of 21, co-authored 54 publications receiving 1584 citations. Previous affiliations of Egidio Stigliano include The Catholic University of America.
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Journal ArticleDOI
VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis
Franco Scaldaferri,Stefania Vetrano,Miquel Sans,Vincenzo Arena,Giuseppe Straface,Egidio Stigliano,Alessandro Repici,Andreas Sturm,Alberto Malesci,Julián Panés,Seppo Ylä-Herttuala,Claudio Fiocchi,Silvio Danese +12 more
TL;DR: VEGF-A appears to be a novel mediator of IBD by promoting intestinal angiogenesis and inflammation, and agents that block VEGf-A signaling might reduce intestinal inflammation in patients with IBD.
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Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration.
Giuseppe Straface,Tamar Aprahamian,Andrea Flex,Eleonora Gaetani,Federico Biscetti,Roy C. Smith,Giovanni Pecorini,Enrico Pola,Flavia Angelini,Egidio Stigliano,John J. Castellot,Douglas W. Losordo,Roberto Pola,Roberto Pola +13 more
TL;DR: It is demonstrated that Shh is de novo expressed after injury and during regeneration of the adult skeletal muscle and displays pleiotropic angiogenic and myogenic potentials in post‐natal life.
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Selective Activation of Peroxisome Proliferator–Activated Receptor (PPAR)α and PPARγ Induces Neoangiogenesis Through a Vascular Endothelial Growth Factor–Dependent Mechanism
Federico Biscetti,Eleonora Gaetani,Andrea Flex,Tamar Aprahamian,Teresa Hopkins,Giuseppe Straface,Giovanni Pecorini,Egidio Stigliano,Roy C. Smith,Flavia Angelini,John J. Castellot,Roberto Pola +11 more
TL;DR: These findings demonstrate that PPARα and PPARγ activation stimulates neoangiogenesis through a VEGF-dependent mechanism, which might have important implications for the clinical and therapeutic management of type 2 diabetes.
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High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism
Federico Biscetti,Giuseppe Straface,Raimondo De Cristofaro,Stefano Lancellotti,Paola Rizzo,Vincenzo Arena,Egidio Stigliano,Giovanni Pecorini,Kensuke Egashira,Giulia De Angelis,Giovanni Ghirlanda,Andrea Flex +11 more
TL;DR: The results of this study show that endogenous HMGB1 is crucial for ischemia-induced angiogenesis in diabetic mice and thatHMGB1 protein administration enhances collateral blood flow in the ischemic hind limbs of diabetic mice through a VEGF-dependent mechanism.
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Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.
Annalaura Brai,Roberta Fazi,Cristina Tintori,Claudio Zamperini,Francesca Bugli,Maurizio Sanguinetti,Egidio Stigliano,José A. Esté,Roger Badia,Sandra Franco,Miguel Angel Martinez,Javier Martínez,Andreas Meyerhans,Francesco Saladini,Maurizio Zazzi,Anna Garbelli,Giovanni Maga,Maurizio Botta +17 more
TL;DR: It is shown for the first time, to the knowledge, that the inhibition of DDX3 by a small molecule could be successfully exploited for the development of a broad spectrum antiviral agent.