F
Federico Biscetti
Researcher at Catholic University of the Sacred Heart
Publications - 68
Citations - 1563
Federico Biscetti is an academic researcher from Catholic University of the Sacred Heart. The author has contributed to research in topics: Diabetes mellitus & Angiogenesis. The author has an hindex of 19, co-authored 57 publications receiving 1150 citations. Previous affiliations of Federico Biscetti include University of Padua & The Catholic University of America.
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Journal ArticleDOI
Sonic hedgehog regulates angiogenesis and myogenesis during post-natal skeletal muscle regeneration.
Giuseppe Straface,Tamar Aprahamian,Andrea Flex,Eleonora Gaetani,Federico Biscetti,Roy C. Smith,Giovanni Pecorini,Enrico Pola,Flavia Angelini,Egidio Stigliano,John J. Castellot,Douglas W. Losordo,Roberto Pola,Roberto Pola +13 more
TL;DR: It is demonstrated that Shh is de novo expressed after injury and during regeneration of the adult skeletal muscle and displays pleiotropic angiogenic and myogenic potentials in post‐natal life.
Journal ArticleDOI
Selective Activation of Peroxisome Proliferator–Activated Receptor (PPAR)α and PPARγ Induces Neoangiogenesis Through a Vascular Endothelial Growth Factor–Dependent Mechanism
Federico Biscetti,Eleonora Gaetani,Andrea Flex,Tamar Aprahamian,Teresa Hopkins,Giuseppe Straface,Giovanni Pecorini,Egidio Stigliano,Roy C. Smith,Flavia Angelini,John J. Castellot,Roberto Pola +11 more
TL;DR: These findings demonstrate that PPARα and PPARγ activation stimulates neoangiogenesis through a VEGF-dependent mechanism, which might have important implications for the clinical and therapeutic management of type 2 diabetes.
Journal ArticleDOI
High-Mobility Group Box-1 Protein Promotes Angiogenesis After Peripheral Ischemia in Diabetic Mice Through a VEGF-Dependent Mechanism
Federico Biscetti,Giuseppe Straface,Raimondo De Cristofaro,Stefano Lancellotti,Paola Rizzo,Vincenzo Arena,Egidio Stigliano,Giovanni Pecorini,Kensuke Egashira,Giulia De Angelis,Giovanni Ghirlanda,Andrea Flex +11 more
TL;DR: The results of this study show that endogenous HMGB1 is crucial for ischemia-induced angiogenesis in diabetic mice and thatHMGB1 protein administration enhances collateral blood flow in the ischemic hind limbs of diabetic mice through a VEGF-dependent mechanism.
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Sarilumab use in severe SARS-CoV-2 pneumonia.
Elisa Gremese,Antonella Cingolani,Silvia Laura Bosello,Stefano Alivernini,Barbara Tolusso,Simone Perniola,Francesco Landi,Maurizio Pompili,Rita Murri,Angelo Santoliquido,Matteo Garcovich,Michela Sali,Gennaro De Pascale,Maurizio Gabrielli,Federico Biscetti,Massimo Montalto,Alberto Tosoni,Giovanni Gambassi,Gian Ludovico Rapaccini,Amerigo Iaconelli,Lorenzo Zileri Del Verme,Luca Petricca,Anna Laura Fedele,Marco Maria Lizzio,Enrica Tamburrini,Gerlando Natalello,L. Gigante,Dario Bruno,Lucrezia Verardi,Eleonora Taddei,Angelo Calabrese,Francesco Lombardi,Roberto Bernabei,Roberto Cauda,Francesco Franceschi,Raffaele Landolfi,Luca Richeldi,Maurizio Sanguinetti,Massimo Fantoni,Massimo Antonelli,Antonio Gasbarrini +40 more
TL;DR: IL-6R inhibition appears to be a potential treatment strategy for severe SARS-CoV-2 pneumonia and intravenous Sarilumab seems a promising treatment approach showing, in the short term, an important clinical outcome and good safety.
Journal ArticleDOI
Pro-inflammatory genetic profiles in subjects with peripheral arterial occlusive disease and critical limb ischemia.
Andrea Flex,Eleonora Gaetani,Flavia Angelini,Alexandra Sabusco,Carmen Chillà,Giuseppe Straface,Federico Biscetti,Paolo Pola,John J. Castellot,Roberto Pola +9 more
TL;DR: This study evaluated distribution and reciprocal interaction of a set of functionally important polymorphisms of genes encoding prototypical inflammatory molecules in subjects with peripheral arterial occlusive disease and critical limb ischemia and investigated whether synergistic interactions between these pro‐inflammatory gene polymorphisms influence the risk of PAOD and CLI.