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Eivind Valen
Researcher at University of Bergen
Publications - 65
Citations - 13223
Eivind Valen is an academic researcher from University of Bergen. The author has contributed to research in topics: Ribosome profiling & Gene. The author has an hindex of 31, co-authored 62 publications receiving 11056 citations. Previous affiliations of Eivind Valen include Harvard University & University of Copenhagen.
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Systematic Clustering of Transcription Start Site Landscapes
TL;DR: This study developed a new non-parametric dissimilarity measure and clustering approach to explore the similarities and stabilities of clusters of TSSDs and demonstrated that in addition to the previous broad/sharp dichotomy an additional category of promoters exists.
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tailfindr: alignment-free poly(A) length measurement for Oxford Nanopore RNA and DNA sequencing
Maximilian Krause,Adnan M. Niazi,Kornel Labun,Yamila N. Torres Cleuren,Florian S. Müller,Eivind Valen +5 more
TL;DR: Tailfindr, an R package to estimate poly(A) tail length on ONT long-read sequencing data, is presented, demonstrating that tailfindr is a versatile tool providing poly( a) tail estimates across a wide range of sequencing conditions.
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REPARATION: ribosome profiling assisted (re-)annotation of bacterial genomes.
TL;DR: RibosomeE Profiling Assisted (re-)AnnotaTION (REPARATION) is a de novo machine learning algorithm that takes advantage of experimental protein synthesis evidence from ribosome profiling (Ribo-seq) to delineate translated open reading frames (ORFs) in bacteria, independent of genome annotation.
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Chromatin accessibility established by Pou5f3, Sox19b and Nanog primes genes for activity during zebrafish genome activation.
TL;DR: The results show that the maternally provided transcription factors Pou5f3, Sox19b, and Nanog open up chromatin and prime genes for activity during zygotic genome activation in zebrafish.
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Accurate analysis of genuine CRISPR editing events with ampliCan.
Kornel Labun,Xiaoge Guo,Alejandro Chavez,George M. Church,George M. Church,James A. Gagnon,Eivind Valen +6 more
TL;DR: The ampliCan tool as discussed by the authors is an analysis tool for genome editing that unifies highly precise quantification and visualization of genuine genome editing events, including insertions, deletions, HDR repair, and targeted base editing.