E
Elena C. McCoy
Researcher at New York Medical College
Publications - 21
Citations - 1731
Elena C. McCoy is an academic researcher from New York Medical College. The author has contributed to research in topics: Salmonella & Nitroreductase. The author has an hindex of 16, co-authored 21 publications receiving 1714 citations.
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Journal ArticleDOI
Nitropyrenes: isolation, identificaton, and reduction of mutagenic impurities in carbon black and toners.
Herbert S. Rosenkranz,Elena C. McCoy,Sanders Daniel R,Marsha A. Butler,Demosthenes K. Kiriazides,Robert Mermelstein +5 more
TL;DR: Nitropyrenes are potent frameshift mutagens, and possible mechanisms for their biological action are discussed.
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The extraordinary mutagenicity of nitropyrenes in bacteria.
Robert Mermelstein,Demosthenes K. Kiriazides,Marsha A. Butler,Elena C. McCoy,Herbert S. Rosenkranz +4 more
TL;DR: The mutagenicity of nitropyrenes is enhanced when resting rather than growing bacterial cultures are used, and the penultimate intermediates responsible for mutagenic activity are not obtained in all instances by reduction of the nitro function.
Journal ArticleDOI
Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escherichia coli.
Virginia C. Dunkel,Errol Zeiger,David Brusick,Elena C. McCoy,Douglas McGregor,Kristien Mortelmans,Herbert S. Rosenkranz,Vincent F. Simmon +7 more
TL;DR: The intra- and interlaboratory reproducibility of the Salmonella assay with regard to the overall judgment of mutagenic or nonmutagenic was good, but the results in the E coli strain exhibited a high degree of variability between laboratories.
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Evidence for the existence of a family of bacterial nitroreductases capable of activating nitrated polycyclics to mutagens.
TL;DR: A derivative of Salmonella typhimurium TA98 which does not respond to the potent mutagenicity of 1,8-dinitropyrene is described and appears to be deficient in a nitroreductase which reduces nitrated pyrenes and possibly other nitrated polycyclic aromatic hydrocarbons to corresponding hydroxylamines, the penultimate mutagens.
Journal ArticleDOI
Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol
Virginia C. Dunkel,Errol Zeiger,David Brusick,Elena C. McCoy,Douglas B. McGregor,Kristien Mortelmans,Herbert S. Rosenkranz,Vincent F. Simmon +7 more
TL;DR: The authors decided to compare the animal species and strains used by the National Cancer Institute/National Toxicology Program (NCI/NTP) for animal carcinogenicity studies.