E
Elena Edelman
Researcher at Duke University
Publications - 4
Citations - 256
Elena Edelman is an academic researcher from Duke University. The author has contributed to research in topics: Gene expression profiling & Tumor progression. The author has an hindex of 4, co-authored 4 publications receiving 252 citations.
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Journal ArticleDOI
A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities
Katherine S. Garman,Chaitanya R. Acharya,Elena Edelman,Marian Grade,Jochen Gaedcke,Shivani Sud,William T. Barry,Anna Mae Diehl,Dawn Provenzale,Geoffrey S. Ginsburg,B. Michael Ghadimi,Thomas Ried,Joseph R. Nevins,Sayan Mukherjee,David S. Hsu,Anil Potti +15 more
TL;DR: A 50-gene signature was developed that effectively distinguished early stage colon cancer patients with a low or high risk of disease recurrence, and an ability to move beyond current staging by refining the estimation of prognosis in early stage Colon cancer also has implications for individualized therapy.
Journal ArticleDOI
Modeling Cancer Progression via Pathway Dependencies
TL;DR: This work introduces an integrative hierarchical analysis of tumor progression that discovers which a priori defined pathways are relevant either throughout or in particular steps of progression, and refinement of the relevant pathways to those genes most differentially expressed in particular disease stages.
Journal ArticleDOI
Analysis of sample set enrichment scores
Elena Edelman,Alessandro Porrello,Justin Guinney,Bala S. Balakumaran,Andrea Bild,Phillip G. Febbo,Sayan Mukherjee +6 more
TL;DR: A formal statistical method to measure the enrichment of each sample in an expression dataset and shows that gene sets built from a model system are indeed enriched in the model system, and employs ASSESS for the use of molecular classification by pathways.
Journal ArticleDOI
Retraction for Garman et al: A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.
Katherine S. Garman,Chaitanya R. Acharya,Elena Edelman,Marian Grade,Jochen Gaedcke,Shivani Sud,William T. Barry,Anna Mae Diehl,Dawn Provenzale,Geoffrey S. Ginsburg,B. Michael Ghadimi,Thomas Ried,Joseph R. Nevins,Sayan Mukherjee,David S. Hsu,Anil Potti +15 more
TL;DR: The editors wish to note that because of several factual and typographical errors, this article is retracting.