J
John G. Gribben
Researcher at Queen Mary University of London
Publications - 661
Citations - 38389
John G. Gribben is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Chronic lymphocytic leukemia & Transplantation. The author has an hindex of 46, co-authored 612 publications receiving 34345 citations. Previous affiliations of John G. Gribben include University of London & University of California, Los Angeles.
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Journal ArticleDOI
Cloning of B7-2: A CTLA-4 counter-receptor that costimulates human T cell proliferation
Gordon J. Freeman,John G. Gribben,Vassiliki A. Boussiotis,Judy W. Ng,Vincent A. Restivo,Lisa A. Lombard,Gary S. Gray,Lee M. Nadler +7 more
TL;DR: A counter-receptor of CD28 and CTLA-4 is cloned, termed B7-2, which also costimulates IL-2 production and T cell proliferation and is likely to provide a critical early costimulatory signal determining if the T cell will contribute to an immune response or become anergic.
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ZAP-70 Compared with Immunoglobulin Heavy-Chain Gene Mutation Status as a Predictor of Disease Progression in Chronic Lymphocytic Leukemia
Laura Z. Rassenti,Lang Huynh,Tracy L. Toy,Liguang Chen,Michael J. Keating,John G. Gribben,Donna Neuberg,Ian W. Flinn,Kanti R. Rai,John C. Byrd,Neil E. Kay,Andrew W. Greaves,Arthur Weiss,Thomas J. Kipps +13 more
TL;DR: Although the presence of an unmutated IgV(H) gene is strongly associated with the expression of Zap-70, ZAP-70 is a stronger predictor of the need for treatment in B-cell CLL.
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Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma.
Anupama Reddy,Jenny Zhang,Nicholas S. Davis,Andrea B. Moffitt,Cassandra Love,Alexander Waldrop,Sirpa Leppä,Annika Pasanen,Leo Meriranta,Marja-Liisa Karjalainen-Lindsberg,Peter Nørgaard,Mette Merete Pedersen,Anne O. Gang,Estrid Høgdall,Tayla Heavican,Waseem Gul Lone,Javeed Iqbal,Qiu Qin,Guojie Li,So Young Kim,Jane Healy,Kristy L. Richards,Yuri Fedoriw,Leon Bernal-Mizrachi,Jean L. Koff,Ashley D. Staton,Christopher R. Flowers,Ora Paltiel,Neta Goldschmidt,Maria Calaminici,Andrew Clear,John G. Gribben,Evelyn T. Nguyen,Magdalena Czader,Sarah L. Ondrejka,Angela M. B. Collie,Eric D. Hsi,Eric Tse,Rex Au-Yeung,Yok-Lam Kwong,Gopesh Srivastava,William W.L. Choi,Andrew M. Evens,Monika Pilichowska,Manju Sengar,Nishitha Reddy,Shaoying Li,Amy Chadburn,Leo I. Gordon,Elaine S. Jaffe,Shawn Levy,Rachel E. Rempel,Tiffany Tzeng,Lanie Happ,Tushar Dave,Deepthi Rajagopalan,Jyotishka Datta,David B. Dunson,Sandeep S. Dave +58 more
TL;DR: An integrative analysis of whole-exome sequencing and transcriptome sequencing in a cohort of DLBCL patients is performed to comprehensively define the landscape of 150 genetic drivers of the disease and their functional roles to identify new therapeutic opportunities in the disease.
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Immunologic purging of marrow assessed by PCR before autologous bone marrow transplantation for B-cell lymphoma.
John G. Gribben,Arnold S. Freedman,Donna Neuberg,Denis-Claude Roy,K Blake,S D Woo,Michael L. Grossbard,SN Rabinowe,F Coral,Gordon J. Freeman +9 more
TL;DR: Evidence is provided of the clinical usefulness of ex vivo purging of autologous bone marrow in the treatment of patients with lymphoma and suggest that the reinfusion of malignant cells in autOLOGous marrow contributes to relapse.
Journal ArticleDOI
Human T-cell clonal anergy is induced by antigen presentation in the absence of B7 costimulation.
TL;DR: In a human antigen-specific model system, when tetanus toxoid peptide antigen is presented by cells cotransfected with HLA-DR7 and B7, optimal T-cell proliferation and interleukin 2 production result, demonstrating that it is possible to induce antigen- specific clonal tolerance in human T cells that have been previously sensitized to antigen.