S
Stephen M. Anderton
Researcher at University of Edinburgh
Publications - 119
Citations - 11422
Stephen M. Anderton is an academic researcher from University of Edinburgh. The author has contributed to research in topics: T cell & Experimental autoimmune encephalomyelitis. The author has an hindex of 44, co-authored 117 publications receiving 10317 citations. Previous affiliations of Stephen M. Anderton include Medical Research Council.
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Journal ArticleDOI
B cells regulate autoimmunity by provision of IL-10.
TL;DR: Data show that B cell–derived IL-10 plays a key role in controlling autoimmunity and that recovery was dependent on the presence of autoantigen-reactive B cells.
Journal ArticleDOI
The IUPHAR/BPS Guide to PHARMACOLOGY in 2018: updates and expansion to encompass the new guide to IMMUNOPHARMACOLOGY
Simon D. Harding,Joanna L. Sharman,Elena Faccenda,Christopher Southan,Adam J. Pawson,Sam M. Ireland,Alasdair J. G. Gray,Liam Bruce,Stephen P.H. Alexander,Stephen M. Anderton,Clare E. Bryant,Anthony P. Davenport,Christian Doerig,Doriano Fabbro,Francesca Levi-Schaffer,Michael Spedding,Jamie A. Davies,Nc-Iuphar +17 more
TL;DR: This update describes content expansion, new features and interoperability improvements introduced in the 10 releases since August 2015, and introduces the newly funded project for the Guide to IMMUNOPHARMACOLOGY (GtoImmuPdb, www.guidetoimmunopharmacology.org).
Journal ArticleDOI
IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases
Ping Shen,Toralf Roch,Vicky Lampropoulou,Richard A. O’Connor,Ulrik Stervbo,Ellen Hilgenberg,Stefanie Ries,Van Duc Dang,Yarúa Jaimes,Capucine Daridon,Capucine Daridon,Rui Li,Luc Jouneau,Pierre Boudinot,Siska Wilantri,Imme Sakwa,Yusei Miyazaki,Melanie D. Leech,Rhoanne C. McPherson,Stefan Wirtz,Markus F. Neurath,Kai Hoehlig,Edgar Meinl,Andreas Grützkau,Joachim R. Grün,Katharina Horn,Anja A. Kühl,Thomas Dörner,Thomas Dörner,Amit Bar-Or,Stefan H. E. Kaufmann,Stephen M. Anderton,Simon Fillatreau +32 more
TL;DR: The increased immunity found in mice lacking IL-35 production by B cells was associated with a higher activation of macrophages and inflammatory T cells, as well as an increased function of B cells as antigen-presenting cells (APCs).
Journal ArticleDOI
Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system.
TL;DR: These are the first data demonstrating the direct involvement of CD4+CD25+ regulatory T cells in the natural resolution of autoimmune disease within the target organ.
Journal ArticleDOI
B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells
Tom A. Barr,Ping Shen,Sheila Brown,Vicky Lampropoulou,Toralf Roch,Sarah Lawrie,Boli Fan,Richard A. O’Connor,Stephen M. Anderton,Amit Bar-Or,Simon Fillatreau,David Gray +11 more
TL;DR: In this article, the authors demonstrate that BCDT alleviates central nervous system autoimmunity through ablation of IL-6secreting pathogenic B cells, which is a major mechanism of B cell-driven pathogenesis in T cell-mediated autoimmune disease.