E
Eli B. Nix
Researcher at Northern Ontario School of Medicine
Publications - 19
Citations - 447
Eli B. Nix is an academic researcher from Northern Ontario School of Medicine. The author has contributed to research in topics: Francisella & Francisella tularensis. The author has an hindex of 9, co-authored 16 publications receiving 413 citations. Previous affiliations of Eli B. Nix include University of Victoria & City University of New York.
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Journal ArticleDOI
Comparative Genomic Characterization of Francisella tularensis Strains Belonging to Low and High Virulence Subspecies
Mia D. Champion,Qiandong Zeng,Eli B. Nix,Francis E. Nano,Paul Keim,Paul Keim,Chinnappa D. Kodira,Mark L. Borowsky,Sarah Young,Michael Koehrsen,Reinhard Engels,Matthew D. Pearson,Clint Howarth,Lisa Larson,Jared White,Lucia Alvarado,Mats Forsman,Scott W. Bearden,Anders Sjöstedt,Richard W. Titball,Stephen L. Michell,Bruce W. Birren,James E. Galagan,James E. Galagan +23 more
TL;DR: The findings suggest that in addition to the duplication of the Francisella Pathogenicity Island, and acquisition of individual loci, adaptation by gene loss in the more recently emerged tularensis, holarctica, and mediasiatica subspecies occurred and was distinct from evolutionary events that differentiated these subspecies, and the novicida subspecies from a common ancestor.
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The biochemical properties of the Francisella pathogenicity island (FPI)-encoded proteins IglA, IglB, IglC, PdpB and DotU suggest roles in type VI secretion
Olle M. de Bruin,Barry N. Duplantis,Jagjit S. Ludu,Rebekah F. Hare,Eli B. Nix,Crystal L. Schmerk,Craig S. Robb,Alisdair B. Boraston,Karsten Hueffer,Francis E. Nano +9 more
TL;DR: The results may provide a mechanistic basis for many of the studies that have examined the virulence properties of Francisella mutants in FPI genes, namely that the observed phenotypes of the mutants are the result of the disruption of the FPI-encoded T6SS structure.
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Risk of invasive Haemophilus influenzae type b (Hib) disease in adults with secondary immunodeficiency in the post-Hib vaccine era.
Eli B. Nix,Nicole Hawdon,Sean Gravelle,Birubi Biman,Malcolm Brigden,Saleem Malik,William McCready,Garry Ferroni,Marina Ulanova +8 more
TL;DR: This study provides a rationale for the immunization of some adult patients with secondary immunodeficiency with the pediatric Hib vaccine to achieve protective immunity.
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Virulence of Francisella spp. in Chicken Embryos
TL;DR: It is demonstrated that infection of 7-day-old chicken embryos can be used to evaluate the virulence of attenuated F. tularensis strains.
Journal ArticleDOI
Genetic elements for selection, deletion mutagenesis and complementation in Francisella spp.
Jagjit S. Ludu,Eli B. Nix,Barry N. Duplantis,Olle M. de Bruin,Larry A. Gallagher,Laura M. Hawley,Francis E. Nano +6 more
TL;DR: A number of antibiotic marker cassettes that incorporate a strong F.novicida promoter are constructed, which greatly enhances selection in F. novicida and F. tularensis.