Elisa Fabbrini

TL;DR: It is not clear whether NAFLD causes metabolic dysfunction or whether metabolic dysfunction is responsible for IHTG accumulation, or possibly both, but it is likely that abnormalities in fatty acid metabolism are key factors involved in the development of insulin resistance, dyslipidemia, and other cardiometabolic risk factors associated withNAFLD.

TL;DR: Data demonstrate that IHTG, not VAT, is a better marker of the metabolic derangements associated with obesity, and alterations in tissue fatty acid transport could be involved in the pathogenesis of ectopic triglyceride accumulation by redirecting plasma fatty acid uptake from adipose tissue toward other tissues.

TL;DR: In this paper, the relationship between intrahepatic triglyceride (IHTG) content and insulin action in liver, skeletal muscle, and adipose tissue was determined in nondiabetic obese subjects.

TL;DR: Obese persons with NAFLD have marked alterations in both adipose tissue and liver and hepatic TG metabolism, and fatty acids derived from nonsystemic sources are responsible for the increase in VLDL-TG secretion.

TL;DR: Important evidence is presented that endoplasmic reticulum stress pathways are present in selected tissues of obese humans and that these signals are regulated by marked weight loss and metabolic improvement.