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Nada A. Abumrad
Researcher at Washington University in St. Louis
Publications - 180
Citations - 19858
Nada A. Abumrad is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: CD36 & Fatty acid. The author has an hindex of 70, co-authored 171 publications receiving 17644 citations. Previous affiliations of Nada A. Abumrad include State University of New York System & Stony Brook University.
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Journal ArticleDOI
Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiation. Homology with human CD36.
TL;DR: The data suggest that FAT and CD36 belong to a family of proteins that bind/transport long-chain fatty acids or function as regulators of these processes.
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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
Elisa Fabbrini,Faidon Magkos,B. Selma Mohammed,Terri A. Pietka,Nada A. Abumrad,Bruce W. Patterson,Adewole L. Okunade,Samuel Klein +7 more
TL;DR: Data demonstrate that IHTG, not VAT, is a better marker of the metabolic derangements associated with obesity, and alterations in tissue fatty acid transport could be involved in the pathogenesis of ectopic triglyceride accumulation by redirecting plasma fatty acid uptake from adipose tissue toward other tissues.
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A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism.
Maria Febbraio,Nada A. Abumrad,David P. Hajjar,Kavita Sharma,Wanli Cheng,S. Frieda A. Pearce,Roy L. Silverstein +6 more
TL;DR: Evidence for a functional role for CD36 in lipoprotein/fatty acid metabolism that was previously underappreciated is provided.
Journal ArticleDOI
Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
Stanley Ching-Cheng Huang,Bart Everts,Yulia Ivanova,David O’Sullivan,Marcia Nascimento,Amber M. Smith,Wandy L. Beatty,Latisha Love-Gregory,Wing Y. Lam,Christina M. O’Neill,Cong Yan,Hong Du,Nada A. Abumrad,Joseph F. Urban,Maxim N. Artyomov,Erika L. Pearce,Edward J. Pearce +16 more
TL;DR: In this article, the authors found that the uptake of triacylglycerol substrates via the scavenger receptor CD36 and their subsequent lipolysis by lysosomal acid lipase (LAL) was important for the engagement of elevated oxidative phosphorylation, enhanced spare respiratory capacity (SRC), prolonged survival and expression of genes that together define M2 activation.
Journal ArticleDOI
Identification of Cd36 ( Fat ) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
Timothy J. Aitman,Anne M. Glazier,Caroline A. Wallace,Lisa D. Cooper,Penny J. Norsworthy,Faisal N. Wahid,Khulood M. Al-Majali,Paul M. Trembling,Christopher J. Mann,Carol C. Shoulders,Daniel Graf,Elizabeth St. Lezin,Theodore W. Kurtz,Vladimir Kren,Vladimir Kren,M Pravenec,M Pravenec,Azeddine Ibrahimi,Nada A. Abumrad,Lawrence W. Stanton,James Scott +20 more
TL;DR: It is concluded that Cd36 deficiency underlies insulin resistance, defective fatty acid metabolism and hypertriglyceridaemia in SHR and may be important in the pathogenesis of human insulin-resistance syndromes.