E
Elisabeth D. Galsgaard
Researcher at Novo Nordisk
Publications - 44
Citations - 1645
Elisabeth D. Galsgaard is an academic researcher from Novo Nordisk. The author has contributed to research in topics: Receptor & Cytokine. The author has an hindex of 19, co-authored 39 publications receiving 1536 citations.
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Journal ArticleDOI
Regulation of beta-cell mass by hormones and growth factors.
Jens Høiriis Nielsen,Elisabeth D. Galsgaard,Annette Møldrup,Birgitte Nissen Friedrichsen,Nils Billestrup,Johnny A. Hansen,Ying C. Lee,Carina Carlsson +7 more
TL;DR: A picture is emerging of an integrated network of signaling events acting in concert to control beta-cell mass adaptation to insulin demand, and a role of cell adhesion molecules and the delta-like protein preadipocyte factor 1/fetal antigen 1 (Pref-1/FA-1) in cytokine-induced beta- cell growth and development is indicated.
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Beta cell proliferation and growth factors.
TL;DR: The increasing knowledge about the mechanisms involved in beta cell differentiation and proliferation may lead to new ways of forming beta cells for treatment of diabetes in man.
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Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against interleukin-1β- and interferon-γ-mediated toxicity
Allan E. Karlsen,Sif G. Rønn,Karen Lindberg,Jesper Johannesen,Elisabeth D. Galsgaard,Flemming Pociot,Jens Høiriis Nielsen,Thomas Mandrup-Poulsen,Jørn Nerup,Nils Billestrup +9 more
TL;DR: Influencing SOCS-3 expression represents an approach for affecting cytokine-induced signal transduction at a proximal step in the signal cascade, potentially useful in future therapies aimed at reducing the destructive potential of β-cell cytotoxic cytokines in Type-1 diabetes mellitus, as well as other cytokines-dependent diseases.
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Identification of Tyrosine Residues in the Intracellular Domain of the Growth Hormone Receptor Required for Transcriptional Signaling and Stat5 Activation
Lone Hansen,Xinzhong Wang,John J. Kopchick,Pierre Bouchelouche,Jens Høiriis Nielsen,Elisabeth D. Galsgaard,Nils Billestrup +6 more
TL;DR: It is demonstrated that specific tyrosines in the GH receptor are required for transcriptional signaling possibly by their role in the activation of transcription factor Stat5.
Journal ArticleDOI
Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene.
Elisabeth D. Galsgaard,Fabrice Gouilleux,B Groner,Palle Serup,Jens Høiriis Nielsen,Nils Billestrup +5 more
TL;DR: In this paper, a block mutation was introduced in a gamma-interferon-activated sequence (GAS)-like element (GLE) with the sequence 5'-TTCTGGGAA-3' located in the rat insulin 1 enhancer at position -330 to -322.