E
Elisabeth G. Rens
Researcher at University of British Columbia
Publications - 19
Citations - 462
Elisabeth G. Rens is an academic researcher from University of British Columbia. The author has contributed to research in topics: Cellular Potts model & Cell polarity. The author has an hindex of 7, co-authored 19 publications receiving 302 citations. Previous affiliations of Elisabeth G. Rens include Centrum Wiskunde & Informatica & Delft University of Technology.
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Journal ArticleDOI
Mechanical cell-matrix feedback explains pairwise and collective endothelial cell behavior in vitro.
René F.M. van Oers,Elisabeth G. Rens,Danielle J. LaValley,Cynthia A. Reinhart-King,Roeland M. H. Merks +4 more
TL;DR: A single set of biologically plausible rules describing the contractile forces that endothelial cells exert on the ECM, the resulting strains in the extracellular matrix, and the cellular response to the strains suffices for reproducing the behavior of individual endothelium cells and the interactions of endothelial cell pairs in compliant matrices are shown.
Journal ArticleDOI
Cellular Potts modeling of complex multicellular behaviors in tissue morphogenesis.
Tsuyoshi Hirashima,Elisabeth G. Rens,Elisabeth G. Rens,Roeland M. H. Merks,Roeland M. H. Merks +4 more
TL;DR: The cellular Potts model (CPM; also known as the Glazier‐Graner‐Hogeweg model), an effective computational modeling framework, is reviewed, discussing its usability for modeling complex developmental phenomena.
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From energy to cellular forces in the Cellular Potts Model: An algorithmic approach.
TL;DR: It is shown that a CPM model with internal signaling can be associated with retraction-protrusion forces that accompany cell shape changes and migration, and forces exerted by cells on one another in classic cell-sorting experiments.
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Cell Shape and Durotaxis Explained from Cell-Extracellular Matrix Forces and Focal Adhesion Dynamics.
TL;DR: A hybrid cellular Potts and finite-element model extended with ODE-based models of focal adhesion turnover shows that the full range of cell shape and durotaxis can be explained in unison from dynamics of FAs, in contrast to previous mathematical models.
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Cell Contractility Facilitates Alignment of Cells and Tissues to Static Uniaxial Stretch
TL;DR: A computational model shows that by amplifying local strain cues, active cell contractility can facilitate and accelerate the reorientation of single cells to static strains and predict that the magnitude of the uniaxial stretch and the strength of the contractile forces regulate a gradual transition between stringlike patterns and vascular networklike patterns.