Elisabeth Lopez

TL;DR: Inoculation of pigs with the deletion mutant virus BA71ΔCD2 protected pigs not only against experimental challenge with BA71, the virulent parental strain, but also against heterologous viruses, including Georgia 2007/1, the genotype II strain of ASFV currently circulating in Eastern Europe.

TL;DR: Despite their inherent disadvantages, LAVs will be the first technology to reach the market, while subunit vaccines will need much further research to become a successful commercial reality, although far from the efficacy achieved by LAVs, sub unit vaccines are the optimal choice for the future.

TL;DR: Interestingly, the deletion of the I329L gene failed to attenuate the virulent Georgia/2007 isolate, and a significant increase in IL-10 levels in serum was observed in pigs immunised with OURT88/3ΔI329L following challenge.

TL;DR: In this article, the authors used BA71∆CD2 as a tool trying to understand ASFV cross-protection, using phylogenetically distant strains, and found that crossprotection is a multifactorial phenomenon that not only depends on sequence similarity.

TL;DR: The present work demonstrates that warthog FMT is not harmful for domestic weaned piglets, while it modifies their gut microbiota; and that FMT from warthogs to pigs confers partial protection against attenuated ASFV strains.